PIGR-1, a member of immunoglobulin gene superfamily

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 6, 435 701, 4353201, 435326, 435348, 435354, 435363, 435419, 4352523, 43525411, 536 231, 536 2353, C12N 1500, C12Q 168, C07H 2104, C07K 14705

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active

060201614

ABSTRACT:
PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.

REFERENCES:
GenBank Accession No. X66171 (Aug. 2, 1993).
EST #2175917.
Jackson, David G., et al., "Molecular cloning of a novel member of the immunoglobulin gene homologous to the polymeric immunoglobulin receptor", Eur. J. Immunol. 22:1157-1163, (1992).
Danish, A., et al., "Expression of the CMRF-35 antigen, a new member of the immunoglobulin gene superfamily, is differentially regulated on leucocytes", Immunology 79:55-63, (1993).

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