Piezoelectric cantilever sensors

Details Piezoelectric cantilever sensors Piezoelectric cantilever sensors

2004-10-27

2008-12-02

Williams, Hezron E. (Department: 2856)

Measuring and testing

Vibration

Resonance, frequency, or amplitude study

C073S073000, C073S061750, C073S580000

Reexamination Certificate

active

07458265

ABSTRACT:
A piezoelectric cantilever with a non-piezoelectric, or piezoelectric tip useful as mass and viscosity sensors. The change in the cantilever mass can be accurately quantified by monitoring a resonance frequency shift of the cantilever. For bio-detection, antibodies or other specific receptors of target antigens may be immobilized on the cantilever surface, preferably on the non-piezoelectric tip. For chemical detection, high surface-area selective absorbent materials are coated on the cantilever tip. Binding of the target antigens or analytes to the cantilever surface increases the cantilever mass. Detection of target antigens or analytes is achieved by monitoring the cantilever's resonance frequency and determining the resonance frequency shift that is due to the mass of the adsorbed target antigens on the cantilever surface. The use of a piezoelectric unimorph cantilever allows both electrical actuation and electrical sensing. Incorporating a non-piezoelectric tip (14) enhances the sensitivity of the sensor. In addition, the piezoelectric cantilever can withstand damping in highly viscous liquids and can be used as a viscosity sensor in wide viscosity range.

REFERENCES:
patent: 5079199 (1992-01-01), Ochi et al.
patent: 5162691 (1992-11-01), Mariani
patent: 5283037 (1994-02-01), Baer et al.
patent: 5719324 (1998-02-01), Thundat
patent: 5742377 (1998-04-01), Minne
patent: 5883705 (1999-03-01), Minne
patent: 6252335 (2001-06-01), Nilsson
patent: 6289717 (2001-09-01), Thundat
patent: 6336366 (2002-01-01), Thundat
patent: 6545273 (2003-04-01), Singh
patent: 6813815 (2004-11-01), Namerikawa et al.
patent: 7061166 (2006-06-01), Kuniyasu
patent: 7089813 (2006-08-01), Takeuchi et al.
patent: 7262546 (2007-08-01), Namerikawa et al.
patent: 7329536 (2008-02-01), Zeng et al.
patent: 2005/0248235 (2005-11-01), Namerikawa et al.
patent: 2006/0123910 (2006-06-01), Cunningham et al.
patent: 2007/0089519 (2007-04-01), Hao et al.
patent: 2008/0035180 (2008-02-01), Mutharasan et al.
Shih, Wan Y. et al, Simultaneous Liquid Viscosity and Density Determination with Piezoelectric Unimorph Cantilevers, Journal of Applied Physics, Jan. 15, 2001, pp. 1497-1505, vol. 89, No. 2, American Institute of Physics, USA.
Yi, Jeong Woo et al., Effect of Length, Width, and Mode on the Mass Detection Sensitivity of Piezoelectric Unimorph Cantilevers, Journal of Applied Physics, Feb. 1, 2002, pp. 1-7, vol. 91, No. 3, American Institute of Physics, USA.
Yi, Jeong W. et al., In Situ Cell Detection using Piezoelectric Lead Zirconate Titanate-Stainless Steel Cantilevers, Jan. 1, 2003, pp. 619-625, vol. 93, No. 1, American Institute of Physics, USA.
Thaysen, J. et al., Cantilever-Based Bio-Chemical Sensor Integrated in a Microliquid Handling System, 2001, pp. 401-404.
L, Junjun et al., Micromachined Biomimetic Sensor Using Modular Artificial Hair Cells, pp. 1-3.
Thaysen, J., Label Free Detection, BioMEMs Materials and Fabrication Methods, Track 2, 3:00pm, Sep. 7, 2002, pp. 1-3.
Lee, Chengkuo et al., Self-Excited Piezoelectric PZT Micorantilevers for Dynamic SFM—With Inherent Sensing and Actuating Capabilities, Sensors and Actuators A72, 1999, pp. 179-188.
Huiming Gu et al., Single-Calcination Synthesis of Pyrochlore-Free 0.9Pb(Mg 1/3NB2/3)O3-0. 1PbTiO3 and Pb (Mg1/3Nb2/3)O3 Ceramics Using a Coating Method, Journal of the American Ceramic Society, 2003, pp. 217-221, vol. 86, No. 2.

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