Picromycin resistance-conferring gene, designated pica, for use

Details Picromycin resistance-conferring gene, designated pica, for use Picromycin resistance-conferring gene, designated pica, for use

1988-07-29

1991-10-15

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 435 711, 435 34, 435 91, 435169, 4351721, 4351723, 4353201, 435886, 536 27, 935 6, 935 9, 935 22, 935 29, 935 33, 935 38, 935 39, 935 59, 935 66, 935 72, 935 75, C12N 121, C12N, C12N, C12N 1570, C12N 1574

Patent

active

050574256

ABSTRACT:
A novel gene conferring resistance to picromycin in Streptomyces and related organisms was cloned from a genomic library of Streptomyces felleus DNA. The novel picromycin resistance-conferring gene can be isolated on an .about.2.8 kb PvuII fragment by subcloning the restriction fragment from plasmid pOJ321. This PvuII fragment contains all of the information required for the expression of the picromycin resistant phenotype in Streptomyces. Methods for inducing resistance, as well as vectors and transformants containing the novel picromycin resistance gene, are provided.

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