Picosulfate dosage form

Details Picosulfate dosage form Picosulfate dosage form

1995-07-06

1997-05-20

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424464, 514892, A61K 964

Patent

active

056310226

ABSTRACT:
A pharmaceutical laxative composition in unit dosage form, for peroral administration of picosulphate to a human or other animal subject, comprising a safe and effective amount of picosulphate in a rapidly dissolving matrix; and a proximal colonic delivery carrier which effects release of said picosulphate substantially near the junction between the small intestine and the colon or within the colon of said subject. This invention also involves methods for providing laxation for humans and other animals in need thereof by peroral administration of such compositions.

REFERENCES:
patent: 2870061 (1959-01-01), Huggins
patent: 3080286 (1963-03-01), Neary
patent: 4369172 (1983-01-01), Schor
patent: 4690816 (1987-09-01), Hata et al.
patent: 4948591 (1990-08-01), Yamada
patent: 5068110 (1991-11-01), Fawzi
patent: 5194464 (1993-03-01), Itoh
Hillestad, B., R. B. Sund, and M. Buajordet "Intestinal Handling of Bisacodyl and Picosulphate by Everted Sacs of the Rat Jejunum and Stripped Colon", Acta pharmacol. el toxicol., vol. 51 (1982), pp. 388-394.
Jauch, R., R. Hankewitz, K. Beschke, and H. Pelzer "Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The Common Laxative Principle of Bisacodyl and Sodium Picosulfate", Arzneim.-Forsch. (Drug Res.), vol. 25 (1975), No. 11, pp. 1796-1800.
Pala, G., G. Coppi and E. Crescenzi "On the Laxative Properteis of Sulfuric Esters of Phenols, with Particular Reference to 4,4'-(2-picolylidene)-bis-phenylsulfuric Acid Disodium Salt (Picosulfol)", Arch. int. Pharmacodyn., vol. 164 (1966), No. 2, pp. 356-369.
Sund, R. B., K. Songedal, T. Harestad, B. Salvesen, and S. Kristiansen "Enterohepatic Circulation, Urinary Excretion and Laxative Action of Some Bisacodyl Derivatives after Intragastric Administration in the Rat" Acta pharmacol. et toxicol., vol. 48 (1981), pp. 73-80.
Sund, R. B. "Aspects of the Pharmacology of Diphenylmethane Laxatives (Bisacodyl, Oxphenisatin and Phenolphthalein derivatives)", Nor. Pharm. Acta, vol. 45 (1983), pp. 125-162.

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