Picosulfate-containing preparation for colonic evacuation

Details Picosulfate-containing preparation for colonic evacuation Picosulfate-containing preparation for colonic evacuation

1996-10-31

1999-01-12

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424458, 424463, 424464, 424489, 424 7801, 424709, A61K 964

Patent

active

058584030

ABSTRACT:
An osmotic colonic evacuant in solid dosage form, which comprises a phosphate based laxative or a sulfate based laxative and preferably comprises sodium picosulfate and an antacid, is used preferably in conjunction with 250 ml to 1,500 ml diluent, alone or as part of a sequential pack, to evacuate the colon, to treat small bowel bacterial overgrowth, irritable bowel syndrome, and acute or chronic bacterial bowel infections.

REFERENCES:
patent: 5616346 (1997-04-01), Aronchick
Bergin, A. J., et al. "The effect of preliminary bowel preparation on a simple test of colonic transport in constipated subjects," from International Journal for Colorectal Disease, 8(2), 75-77 (1993).
Corazziari, E., et al, Digestive Diseases and Sciences 41(8) 1636-1642 (1996).
Liacouras, C. A., et al, J. Clin. Gastroenterol 22(3), 186-189 (1996).
The Extra Pharmacopoeia/Martindale, 30th edition, Reynolds, J.E.F., editor, Pharmaceutical Press, London (1993), pp. 858-860.
Izzo et al. "Nitric Oxide as a Mediator of the Laxative Action of Magnesium Sulphate", British Journal of Pharmacology, vol. 113, No. 1(Sep. 1994), pp. 228-232. Abstract Only.
Liacouras et al. "Whole-Bowel Irrigation As an Adjunct to the Treatment of Chronic, Relapsing Clostridium Difficile Colitis", Journal of Clinical Gastroenterology, vol. 22, No. 2(1996), pp. 186-189.
Goldberg et al. A Study of a New Osmotic Purgative for Colonoscopy. Is Golytely Worth its Salt?, Surgical Endoscopy, vol. 9, No. 3(Mar. 1995), pp. 329-331. Abstract Only.
Izzo et al. "The Osmotic and Intrinsic Mechanisms of the Pharmacological Laxative Action of Oral High Doses of Magnesium Sulphate, Importance of the Release of Digestive Polypeptides and Nitric Oxide". Magnesium Research, vol. 9, No. 2 (Jun. 1996) pp. 133-138, Ref: 35 Abstract Only.
Araki et al. "A Study on Polyethylene Glycol Electrolyte Lavage Solution and Sodium Picosulfate Combined Pretreatment Method for Colonoscopy", Kurume Medical Journal, vol. 39, No. 2(1992), pp. 117-121.
Chapman et al. "Antibacterial Activity of Bowel-Cleansing Agents: Implications of Antibacteroides Activity of Senna", British Journal of Surgery, vol. 82, No. 8(1995 Aug.), p. 1053.

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