Chemistry: molecular biology and microbiology – Vector – per se
Patent
1991-09-18
1997-09-09
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Vector, per se
435938, 935 22, 935 66, 935 69, C12N 1563, C12N 1581
Patent
active
056656009
ABSTRACT:
Two novel linear DNA plasmids are described. Also, novel fragments of the plasmids containing the autonomous replication sequence (ARS), and thus capable of self-maintenance as extra chromosomal elements are provided. These novel DNA sequences of the present invention are useful in a vector for self-maintenance in Pichia pastoris and are also useful as plasmid vectors which can be shuttled between yeast and bacteria.
REFERENCES:
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patent: 4477571 (1984-10-01), Chang et al.
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Cregg et al., (1985) "Pichia pastoris as a host system for transformations," Molecular and Cellular Biology vol. 5, No. 12, pp. 3376-3385.
Gunge et al., "Isolation and Characterization of Linear Deoxyribonucleic Acid Plasmids from Kluyveromyces Lactis & the Plasmid Associated Killer Character", vol. 145 Journal of Bacteriology, pp. 382-390 (Jan. 1981).
Hirochika H. et al. "Analysis of Linear Plasmids Isolated Streptomyces: Association of Protein with the Ends of the Plasmid DNA", vol. 1, Plasmid 7, pp. 59-65 (1982).
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Barr Kathryn A.
Gaertner Frank H.
Hagenson Mary Jane
Harpold Michael M.
Klein Ronald D.
Degen Nancy J.
Fleisher Mindy
Research Corporation Technologies Inc.
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