Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined...
Patent
1994-09-27
1996-10-01
Rollins, John W.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
424529, 424548, 424557, 424558, 424559, 424562, 424563, 424570, 424683, 424684, 424704, 424723, 514769, 514825, 514886, A61K 31275, A61K 31215, A61K 31225, A61K 3119
Patent
active
055609350
ABSTRACT:
The present invention provides a physiologically active substance which inhibits plasma kallikrein production, improves peripheral blood flow, and exhibits analgesic, antiinflammatory and antiallergic action. The physiologically active substance of the present invention is prepared by activating various animals or animal tissues by means of inoculation with virus or tumor cells which act as a stressor, and then extracting the effective factor from the activated tissues. The substance exhibits a pharmacological action of inhibiting activity for production of plasma kallikrein and recovering and normalizing abnormal functions which are associated with the diseased state. The physiologically active substance and pharmaceutical compositions of the present invention exhibit excellent regulating activity for biofunctions. They provide recovery and normalization of abnormal functions in living organisms in various diseased states. The compositions are useful as pharmaceuticals such as peripheral blood flow improving agents, analgesic agents, antiinflammatory agents and antiallergic agents. The physiologically active composition which is extracted from the activated tissue comprises an amorphous and hygroscopic powder containing 1-20 micrograms/mg of at least one silicon component calculated as silicon such as a water-soluble silicic acid, water-soluble silicate, a polymer of a water-soluble silicic acid, and a polymer of a water-soluble silicate. The powder is soluble in water, methanol and ethanol and is insoluble in benzene and ether. The powder may have a pH of 6.0 to 8.3, and ultraviolet absorptions of .lambda..sub.max =265-275 nm.
REFERENCES:
patent: 3959566 (1976-05-01), Pangonis
patent: 4036787 (1977-07-01), Blount
patent: 4039474 (1977-08-01), Feistel et al.
patent: 4056937 (1977-11-01), Suzuki
patent: 4089883 (1978-05-01), Blount
patent: 4138421 (1979-02-01), Blount
patent: 4863518 (1989-09-01), Blount
patent: 4985254 (1991-01-01), Konishi et al.
patent: 4985354 (1991-01-01), Toyomaki et al.
patent: 5013558 (1991-05-01), Konishi
patent: 5057324 (1991-10-01), Shibayama et al.
patent: 5127994 (1992-07-01), Johansson
patent: 5227089 (1993-07-01), Hasegawa et al.
Yokoi, et al., "Effect of Degree of Polymerization of Silicic Acid on the Gastrointestinal Absorption of Silicate in Rats", Chem. Pharm. Bull. , vol. 27, No. 8, 1979, pp. 1733-1739.
Derwent Publications Ltd., London, GB; AN 82-10241J, "Drug For Cultivated Fish", & JP A57183720 (Mitani J.), 12 Nov. 1982, abstract.
"Remedy For Burn", Patent Abstracts of Japan , vol. 7, No. 255 (C-189), 6 Oct. 1983, & JPA58121217 (Kagitani Takeo) 19 Jul. 1983, abstract.
"Drug For Food Poisoning", Patent Abstracts of Japan , vol. 11, No. 371 (C-462), 3 Dec. 1987 & JPA62145022 (Sofuto Shirika) 29 Jun. 1987, abstract.
"Adsorbent For Peroxylipid", Patent Abstracts of Japan , vol. 15, No. 474 (C-890), 3 Dec. 1991 & JPA3204803 (Shiseido Co. Ltd.) 6 Sep. 1991, abstract.
The Merck Index, 9th ed, 1976. No. 7u56, 8443, 8233-8243 & 5514-5515.
Hamada Giichi
Konishi Jin-emon
Nippon Zoki Pharmaceutical Co. Ltd.
Rollins John W.
LandOfFree
Physiologically active substances extracted from activated tissu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Physiologically active substances extracted from activated tissu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Physiologically active substances extracted from activated tissu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1500684