Physiologically active substance tan-931, its derivatives, their

Details Physiologically active substance tan-931, its derivatives, their Physiologically active substance tan-931, its derivatives, their

1989-05-18

1990-06-19

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

544 3, 544 8, 544174, 544176, 544391, 546226, 548127, 548128, 548214, 548578, 560 56, 562440, 562441, 562460, 564167, C07C10322

Patent

active

049355430

ABSTRACT:
A novel compound of the formula (I): ##STR1## wherein R.sub.1 is optionally esterified or amidated carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or halogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and A is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active compound the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.

REFERENCES:
patent: 3903161 (1975-09-01), Kreighbaum et al.
patent: 4172146 (1979-10-01), Karrer
patent: 4208349 (1980-06-01), Watson
patent: 4287191 (1981-09-01), Coburn et al.
Journal of The Chemical Society, Section C, Organic Chemistry, Part II, pp. 1175-1182.

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