Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Patent
1991-07-11
1995-02-21
Russel, Jeffrey E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
4352535, 514 19, 562561, 562564, C07C22908, C12N 120, C12P 2102
Patent
active
053914864
ABSTRACT:
The present invention relates to new stromelysin (human)-inhibitors, i.e., physiologically active substances BE-16627 represented by the general formula: ##STR1## wherein R represents a hydrogen atom or a methyl group, or pharmaceutically acceptable salts thereof, a process for the production and use thereof, and a microorganism producing the substance BE-16627.
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Dispasquale, Gene et al., "Proteoglycan- and Collagen-Degrading Enzymes from Human Interleukin 1-Stimulated Chondrocytes from Several Species: Proteoglycanase and Collagenase Inhibitors as Potentially New Disease-Modifying Antiarthritic Agents," Proceedings of the Society for Experimental Biology and Medicine 183:262-276, 1987.
Wilhelm, Scott M. et al., "Human skin fibroblast stromelysin: Structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells," Proc. Natl. Acad. Sci. USA 84:6725-6729, 1987.
"Metalloproteinase inhibitor-producing Streptomyces strains," Chemical Abstracts 96:197874z, 1982.
Kanbayashi Nobuo
Naito Kyozo
Nakajima Shigeru
Okanishi Masanori
Okuyama Akira
Banyu Pharmaceutical Co. Ltd.
Russel Jeffrey E.
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