Physiologically active substance

Details Physiologically active substance Physiologically active substance

1992-06-17

1994-01-04

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6112

Patent

active

052761770

ABSTRACT:
A novel physiologically active substance is represented by the formula. ##STR1## The substance is preferably derived from propolis, has excellent antitumor activity and is useful as an antitumor drug.

REFERENCES:
patent: 5008441 (1991-04-01), Nakanishi
G. Morales et al., "Diterpenoids and Flavonoids from Baccharis boliviensis, " Chem. Abstr. 1991, 114, 39206u.
S. Scheller et al., "Antitumoral Property of Ethanolic Extract Propolis in Mice Bearing Ehrlich Carcinoma, Compared to Bleomycin," Z. Naturforsch, C, 1989, 44, 1063-1065.
F. Bohlmann et al., "Thirteen Kolavane Derivatives from Symphyopappus Species," Phytochemistry, 1981, 20, 1657-1663.
C. Zdero et al., "Ent-Clerodanes and Other Constituents from Bolivian Baccharis Species," Phytochemistry, 1989, 28, 531-542.
M. Toyota et al., "Clerodane, Laurane and Labdane Diterpenoids from the Liverwort Jungermannia Infusca," Phytochemistry, 1989, 28, 3415-3419.
M. Toyota et al., "Clerodane-type Diterpenic Acid from the Liverwort Jungermannia Infusca," Phytochemistry, 1989, 28, 2507-2509.

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