Physiologically active porcine peptide (CNP-53)

Details Physiologically active porcine peptide (CNP-53) Physiologically active porcine peptide (CNP-53)

1991-07-12

1994-08-23

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 700, A61K 3700, A61K 3702

Patent

active

053409205

ABSTRACT:
A peptide composed of 53 amino acid residues represented by the following amino acid sequence: (see SEQ ID NO: 1) ##STR1## and derivatives thereof represented by the following amino acid sequence: (see SEQ ID NO: 2) ##STR2## wherein X is as shown in the specification, are disclosed. These polypeptides are novel and have natriuretic and hypotensive actions.

REFERENCES:
patent: 4904763 (1990-02-01), Matsuo et al.
patent: 5114923 (1992-05-01), Seilhamer et al.
Tawaragi et al.; "Biochemical and Biophysical Research Communications"; Academic Press Inc: Oct. 30, 1990 pp. 627-632.
Sudoh et al.; "Biochemical and Biophysical Research Communications"; Academic Press, Inc.; Apr. 30, 1990; pp. 863-870.
Minamino et al.; "Biochemical and Biophysical Research Communications"; Academic Press Inc.; Nov. 30, 1988; pp. 402-409.
Minamino et al.; "Biochemical and Biophysical Research Communications"; Academic Press Inc.; Jul. 31, 1990; pp. 973-979.
Tawaragi et al.; "Biochemical and Biophysical Research Communications"; Academic Press Inc.; Oct. 30, 1990; pp. 627-632.

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