Physiologically active polypeptide preparation

Details Physiologically active polypeptide preparation Physiologically active polypeptide preparation

1975-12-02

1976-11-16

Shapiro, Lionel M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 29, C07G 7026

Patent

active

039923649

ABSTRACT:
A physiologically active polypeptide effective for decreasing cholesterol levels and increasing 17 keto-steroid elimination of human patients is prepared by enzymatic proteolysis at temperatures not above 45.degree. C of mammalian organs rich in reticulo-endotelial tissue. The polypeptide has a molecular weight of less than 5,000, an isoelectric point at pH 5.5 and an Rf value between 0.5 and 0.6 in Partridge solution. It may be administered orally or parenterally.

REFERENCES:
patent: 2171320 (1939-08-01), Lautenschlager et al.
patent: 3034963 (1962-05-01), Wachtel
patent: 3498964 (1970-03-01), Hayashi

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