Physiologically-active novel substance "Aldostatin" and producti

Details Physiologically-active novel substance "Aldostatin" and producti Physiologically-active novel substance "Aldostatin" and producti

1987-02-19

1988-06-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424120, 435171, A61K 3570, C12P 102

Patent

active

047495715

ABSTRACT:
A physiologically-active novel substance "aldostatin" having an estimated molecular formula of C.sub.20 H.sub.20 N.sub.2 O.sub.8 is produced by culturing an aldostatin-producing microorganism of the Pseudeurotium, for example, the Pseudeurotium zonatum M4109 strain. Aldostatin inhibits the aldose reductase activity and as a consequence, avoids abnormal accumulation of sorbitol, galactitol, etc. It is therefore effective for the treatment of chronic complications such as cataract, retinopathy and neuropathy caused by diabetes renalis.

REFERENCES:
Chemical Abstracts, Registry No. 13200-86-7 (N-formyltyrosin).

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