Physiologically active erbstatin analogue compounds and composit

Details Physiologically active erbstatin analogue compounds and composit Physiologically active erbstatin analogue compounds and composit

1987-02-20

1990-05-15

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564219, A61K 31165, C07C10338

Patent

active

049258770

ABSTRACT:
The present invention provides new physiological active substance erbstatin analogue compounds of a general formula (I), which have excellent tyrosine-specific protein-kinase inhibitory activity, antitumor activity and antimicrobial activity. ##STR1## (in which R.sup.1 represents a hydrogen atom, a lower alkanoyl group or a lower alkyl group; n represents a positive integer of 1 to 3;

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patent: 4686308 (1987-08-01), Umezawa et al.
Wick et al., I, Chem. Abst., (1981), vol. 94, p. 52, 150252(p).
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Umehara et al., Chem. Abst., (1984), vol. 101, p. 325, 87029(s).
Umezawa et al., II, J. of Antibiotics, (1986), vol. 39, pp. 170-173.

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