Physiologically active compound

Details Physiologically active compound Physiologically active compound

1994-02-18

1995-06-27

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40314

Patent

active

054281750

ABSTRACT:
A physiologically active compound HS-1 having the following chemical structure is disclosed. This compound is prepared by culturing Chromobacterium violaceum, adding tryptophan and diethyldithiocarbamate (diethyldithiocarbamic acid) to the culture broth for reacting with the cells for producing HS-1 in the cells, and collecting the compound from the culture broth. This novel compound possesses antitumor and antimicrobial activity, and is effective as an antitumor agent or an antimicrobial agent. ##STR1##

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Tsutomu Hoshino et al., "Biosynthesis of Violacein: Evidence for the Intermediacy of 5-Hydroxy-L-tryptophan and the structure of a New Pigment, Oxyviolacein, Produced by the Metabolism of 5-Hydroxytryptophan", Agric. Biol. Chem., 54(9):2339-2346 (1990).
Patrick J. Davis, et al., "Metabolism of N-Carbobenzoxyl-L-Tryptophan By Chromobacterium Violaceum", Biochimica et Biophysica Acta, 385(1):133-144 (1975).
Carol H. Letendre, et al., "The Tryptophan Hydroxylase of Chromobacterium Violaceum", The J. of Biological Chemistry, 249(22):7186-7191 (1974).
Tsutomu Hoshino et al., "A New Metabolite of Tryptophan, Chromopyrrolic Acid, Produced by Chromobacterium Violaceum", Bioscience, Biotechnology, And Biochemistry, 57(5):775-781 (1993).
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P. J. Davis et al., "Formation of Indole-3-Carboxylic Acid From Tryptophan by Chromobactyerium Violaceum", J. of Natural Products, 38(6):541 (Nov.-Dec. 1975).

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