Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2007-02-20
2007-02-20
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C424S085100
Reexamination Certificate
active
10668178
ABSTRACT:
Disclosed is a physiologically active complex which comprises a proteinaceous part with TNF activity and a high molecular part bound artificially to the N-terminus of the proteinaceous part. The proteinaceous part in the complex has the amino acid sequence of SEQ ID NO:2 where Xaa is a member selected from the group consisting of asparagine, alanine, arginine, serine, threonine, proline, methionine, and leucine; while the high molecular part in the complex is a homopolymer of polyethylene glycol, copolymer of polyethylene glycol, or a derivative thereof.
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Ikegami Hakuo
Mayumi Tadanori
Nakagawa Shinsaku
Tsutsumi Yasuo
Browdy and Neimark PLLC
Helms Larry R.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Mayumi Tadanori
Nakagawa Shinsaku
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