Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1989-07-06
1992-06-09
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514558, 514560, A61K 3120, A61K 3123
Patent
active
051207630
ABSTRACT:
A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, in order to induce in a mammal (including humans) at least one physiological effect selected from memory enhancement, analgesia, sleep regulation and inhibition of the symptoms of senility, and in order treat Alzheimer's disease and related dementia, and epilepsy.
REFERENCES:
patent: 4058594 (1977-11-01), Williams
patent: 4810497 (1989-03-01), Horribin
Brinkmann, et al. Chemical Abstracts, vol. 103, 1985 Abstract 212685x.
Brinkmann, et al. Chemical Abstracts vol. 96, 1982 Abstract 210912g.
Marx, Science vol. 250, 1990 pp. 1509-1510.
Thompson, et al New England J. of Medicine 323 (7), 1990 pp. 445 to 448.
Gauthier, et al. New England Journal of Medicine 322 pp. 1272-1276, 1990.
Sigman catalogue, 1990, Homs E7134,L1376 L2376, L2378.
Teri, et al. J. of Gerontology: Psyschological Science 199 45(2) pp. p. 58-p. 62.
Applegate, et al. New England Journal of Medicine 322: 1207-1214, 1990.
Berg. Mount Sinai J. of Medicine 55(1) 1988 pp. 87-94.
Burns, et al. International Psychogeriatrics, 2(1) 1990 pp. 25 to 36.
Innis, Sheila M., "Effect of Total Parenteral Nutrition with Linolleic Acid-Rich Emulsions on Tissue w6 and w3 Fatty Acids in the Rat", Lipids, 21(2): 132-8 (1986).
Rahm, J. J. & Holman, R. T., "Effect of Linoleic Acid upon the Metabolism of Linoleic Acid", J. Nutrition, 84(1): 15-19 (1964).
Ciangherotti, S. et al, "Significato nutrizionale dell'acido linolenico", Riv. Ital. Sostanze Grasse, 61(5): 293-6 (1984).
Mohrhauer, H & Holman, R. T., "Effect of Linolenic Acid Upon the Metabolism of Linoleic Acid", J. Nutrition, 81(1): 67-74 (1963).
Budowski, P. & Crawford, M. A., "alpha-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids", Proceedings of the Nutrition Society, 44:221-229 (1985).
Chemical Abstracts 47:10644 reporting Sertoli, P., "Vitamin F99 and the lipid-glucose-protein metabolism II", Pliclinico, Ses. med., 60:194-211 (1953).
Carlson, S. E. et al, "High Fat Diets Varying in Ratios of Polyunsaturated to Saturated Fatty Acid and Linoleic to Linolenic Acid: A Comparison of Rat Neural and Red Cell Membrane Phospholipids" J. Nutrition, 116(5):718-25 (1986).
Bar Ilan University
Shah Mukund J.
Ward E. C.
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