Physiological tear compositions and methods for their preparatio

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Carbonate

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424700, 514912, A61K 3300

Patent

active

054035988

ABSTRACT:
Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.

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Rismondo, V. et al. "Electrolyte Composition of Lacrimal Gland Fluid and Tears of Normal and Vitamin A-Deficient Rabbits," CLAO Journal, 15(3): 222-229 (1989).
Drug Facts and Comparisons, New York: J. B. Lippincott Co., 1989, pp. 504-504b.
Doughty, M. J., "Evidence for a Direct Effect of Bicarbonate on the Rabbit Corneal Stroma," Optometry & Vision Sci., 68(9):687-698 (1989).
Edelhauser, H. et al., "Intraocular Irrigating Solution," Arch. Ophthal., 93:648-657 (1975).
Bachman, W. G. and G. Wilson, "Essential Ions for Maintenance of the Corneal Epithelial Surface," Invest. Ophthal. & Vis. Sci., 26:1484-1488 (1985).
Glasser et al., Chapter 17 of The Cornea: Trans. of the World Congress on the Cornea III (H. D. Cavanagh, ed.), New York: Raven Press Ltd., 1988.

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