Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1977-12-14
1981-09-15
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
424 1, 424 94, 424106, 435 2, A61K 3748, A61K 4300, A61K 3514
Patent
active
042897564
ABSTRACT:
Loaded cells suspended in a physiological solution are prepared in a process in which their volume is expanded by osmotic pressure. Cells so prepared suspended in a physiological solution, when injected into the bloodstream of a living body are preferentially accumulated in the spleen and liver of the body, which treats them as foreign bodies, even though the original cells may have been cells of an animal of the same species. Similarly by storing the loaded cells in a solution containing substances such as glutadialdehyde, formaldehyde that react with the protein phase of membranes or which, like difluoro dinitrobenzene, react with the lipid layer thereof, the loaded cells can also be caused to be broken down by the spleen and/or liver. Premature release of the contents of the loaded cells is prevented and timely release of such contents is assured by incorporating other materials into the loaded cells during the preparation process in accordance with the related application of the same inventors, Ser. No. 859,240 filed Dec. 9, 1977, now U.S. Pat. No. 4,224,313, issued Sept. 23, 1980.
REFERENCES:
patent: 3887698 (1975-06-01), McConnell et al.
U. Zimmermann et al., Biochim. et Biophys. Acta, 436, Jun. 17, 1976, 460-474, Enzyme Loading of Electrically Homogeneous Human Red Blood Cell Ghosts Prepared by Dielectric Breakdown.
T. Steck, Chem. Abst. 77: 30542k (1977), Cross-linking the Major Proteins of the Isolated Erythrocyte Membrane.
U. Zimmermann et al., Z. Naturforsch 29, pp. 304-305 (1974).
C. Colley et al., Chemical Abstracts 83: 22192e, Liposomes as Carriers in Vivo for Methotrexate (1975).
H. Kimelberg, Chemical Abstracts 85: 186467r, Differential Distribution of Liposome-entrapped H.sup.3 -methotrexate and Labeled Lipids after Intravenous Injection in a Primate (1976).
H. Kimelberg et al., Chemical Abstracts 85: 116483u, The Effect of Entrapment in Liposomes on the in Vivo Distribution of H.sup.3 --methotrexate in a Primate (1976).
U. Zimmermann et al., Chemical Abstracts 82: 108324r, Preparation of Erythrocyte Ghosts by Dielectric Breakdown of the Cell Membrane (1975).
U. Zimmermann et al., Chemical Abstracts 81: 75566v, Reversible Dielectric Breakdown of Cell Membranes in Electrostatic Fields (1974).
U. Zimmermann et al., Chemical Abstracts 85: 29784z, Enzyme Loading of _Electrically Homogeneous Human Red Blood Cell Ghosts Prepared by Dielectric Breakdown (1976).
Bock Karin
Buers Hermann J.
Pilwat Gunter
Zimmermann Ulrich
Daus Donald G.
Eakin M. C.
Kernforschungsanlage Julich GmbH
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