Physiological means of enhancing transdermal delivery of drugs

Details Physiological means of enhancing transdermal delivery of drugs Physiological means of enhancing transdermal delivery of drugs

1987-02-13

1989-04-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424 65, 424443, 424447, A61F 1300, A61K 732

Patent

active

048246760

ABSTRACT:
A method of enhancing transdermal delivery of a pharmaceutically active drug from a transdermal delivery system as well as a transdermal delivery system capable of providing a desirable flow interface between the delivery system and the skin surface are disclosed. The method involves pre-treating an area of skin with an anticholinergic agent in an amount sufficient to have a local antisecretory effect on the area treated, such amount being insufficient to cause systemic effects; and applying the transdermal delivery system to the pre-treated area. The delivery system of the present invention is comprised of a carrier means, a pharmaceutically active drug and an anticholinergic agent. With both the method and the delivery system, the anticholinergic agent is preferably a quaternary ammonium salt which is itself transdermally delivered to the area beneath the delivery system in an amount sufficient to suppress perspiration in that area. The suppression of perspiration prevents the formation of an aqueous interface between the skin and delivery system which might prevent drug delivery.

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