Physical trapping type polymeric micelle drug preparation

Details Physical trapping type polymeric micelle drug preparation Physical trapping type polymeric micelle drug preparation

1995-06-05

1996-04-23

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

424 7817, 424450, 424451, 424489, 424501, 42840121, 42840224, A61K 3174, A61K 9127

Patent

active

055101038

ABSTRACT:
The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

REFERENCES:
patent: 5124151 (1992-06-01), Viegas et al.
patent: 5143731 (1992-09-01), Viegas et al.
patent: 5161141 (1992-06-01), Henry
patent: 5219564 (1993-06-01), Zalipsky et al.

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