Phyllanthostatin compounds

Details Phyllanthostatin compounds Phyllanthostatin compounds

1982-02-11

1983-06-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 424181, 536 181, C07H 706, C07H 1300, A61K 3171

Patent

active

043884571

ABSTRACT:
New antineoplastic glycosides, phyllanthostatin 1, 2 and 3, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.

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Spjut, R. W. et al., Cancer Treatment Reports, 60, 979 (1976).
Kupchan, S. M., et al., J. Am. Chem. Soc., 99, 3199 (1977).
Kupchan et al., "Jour. of the Amer. Chem. Soc.", vol. 99, No. 9, Apr. 27, 1977, pp. 3199-3201.
Kupchan et al., "Chem. Abst.", vol. 87, 1977, p 5779s.

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