Phyllanthostatin A

Details Phyllanthostatin A Phyllanthostatin A

1990-01-19

1991-03-05

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 181, A61K 3171, C07H 706, C07H 1300

Patent

active

049978179

ABSTRACT:
An unusal cytostatic (PS ED.sub.50 4 ug/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and is herein designated Phyllanthostatin A. Separation of a methanol extract of the root by size exclusion chromatography, high speed countercurrent distribution and semi-preparative hplc afforded glycoside in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin-B. The structure of the lignan glycoside, determined by hrfabms and 2D nmr spectroscopy, is: ##STR1##

REFERENCES:
patent: 4388457 (1983-06-01), Pettit

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