Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1993-09-02
1996-01-16
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514 43, 514185, 514191, 536 2911, 540123, 540125, 540128, 540140, C09B 4704, C09B 4708, A61K 31555, A61K 31685
Patent
active
054847788
ABSTRACT:
The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) germanium (Ge), gallium (Ga), tin (Sn) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.
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Kenney Malcolm E.
Li Ying-Syi
Oleinick Nancy L.
Rihter Boris D.
Datlow Philip I.
University Hospitals of Cleveland
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