Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1990-07-17
1992-11-24
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
514183, 540128, 556413, C09B 4704, C09B 4708, C07F 718, A61K 3140
Patent
active
051661977
ABSTRACT:
The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy.
REFERENCES:
patent: 3094536 (1963-06-01), Kenney et al.
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"Synthesis and Photocytoxicity of Some New Substituted Phthalocyanines" Photochem. Photobiol. 49, pp. 279-284, 1989; Leznoff et al.
Kane et al., Inorgamic Chemistry, vol. 90, 1970, pp. 1445-1448.
The Merck Manual, 15th Ed., 1987, Robert Berkow Ed., pp. 1219-1220, 1227.
Kenney Malcolm E.
Oleinick Nancy L.
Rihter Boris D.
Datlow Philip I.
Shah Mukund J.
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