Phthalimide compounds and methods of producing same

Details Phthalimide compounds and methods of producing same Phthalimide compounds and methods of producing same

1993-07-21

1995-01-17

Chang, Celia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

546193, A61K 31445, C07D40112

Patent

active

053825896

ABSTRACT:
The present invention relates to phthalimide compounds represented by the following general formula (I) and their acid-added salts and to methods of producing the same: ##STR1## wherein Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--. The present invention provides phthalimide compounds represented by the above general formula (I) and their acid-added salts, which are useful compounds as intermediates of medicines such as anti-ulcers based on histamine H.sub.2 receptor antagonism. In particular, acid-added salts of the phthalimide compounds can be easily refined by the recrystallization method. Therefore, there is provided an advantage that purity of the anti-ulcers which are derived from phthalimide compounds and their acid-added salts according to the present invention can be improved.

REFERENCES:
patent: 4514408 (1985-04-01), Nisato et al.
patent: 4710498 (1987-12-01), Nohara et al.
patent: 4912101 (1990-03-01), Hirakawa et al.
Chemical Abstracts, JP-A-02,121,969, vol. 113: 152270c, 1990.
Chemical Abstracts, JP-A-01,175,968, vol. 112:118663c, 1990.

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