Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-21
2006-11-21
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S367000, C514S375000, C548S456000, C548S473000, C548S202000, C548S159000, C548S235000
Reexamination Certificate
active
07138425
ABSTRACT:
The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine, specifically in the treatment of cancer. (I), wherein X is O or S; R1is a phthalimide carboxylic acid group of formula (II). R is hydrogen, C1–C6alkyl, aryl or C1–C3alkylaryl and R2, R3and R4represent various substituents
REFERENCES:
patent: 63-073425 (1988-04-01), None
patent: 01-247453 (1989-03-01), None
patent: WO 02/060373 (2002-08-01), None
Parish et al. Jul. 15, 1999, Cancer Resarch, 59, 3433-41, p. 3439. This publication is discloed in Applicatn's IDS.
Bashkin, P., et al., “Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules,”Biochem., 1989, 28, 1737-1743.
Database Chemcats Online,CAS, Database Accession No. 1575853, 2001, XP002240053, order No. A0827/0038765, 1 page.
Database Chemcats Online,CAS, Database Accession No. 604372, 2001, XP002240054, order No. CHS 1040578, 1 page.
Database Chemcats Online,CAS, Database Accession No. 126220, 2001, XP002240055, order No. 2922-0873, 1 page.
Demir, M., et al., “Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88),”Clin. Appl. Thromb Hemost, 2001, 7(2), 131-140.
Fang, J., et al., “Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model,”Proc. Natl. Acad. Sci. USA, 2000, 97(8), 3884-3889.
Folkman, J., et al., “Control of angiogenesis by heparin and other sulfated polysaccharides,”Adv. Exp. Med. Biol., 1992, 313, 355-364.
Kondragnati, S., et al., “Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion,”Cancer Res., 2000, 60, 6851-6855.
Parish, C.R., et al., “Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novelin vitroassays for angiogenesis,”Cancer Res., 1999, 59, 3433-3441.
Parish, C.R., et al., “Treatment of central nervous system inflammation with inhibitors of basement membrane degradation,”Immunol.&Cell Biol., 1998, 76, 104-113.
Takuji, H., et al., “Thermoplastic polyester resin composition,”Patent Abstracts of Japan1989, esp@cenet database, 1 page.
Tyle, P., “Iontophoretic devices for drug delivery,”Pharmaceutical Res., 1986, 3(6), 318-326.
Vlodavsky, I., et al., “Inhibition of tumor metastasis by heparanase inhibiting species of heparin,”Invasion Metastasis, 1994-95, 14, 290-302.
Vlodavsky, I., et al., “Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis,”Nature Medicine, 1999, 5(7), 793-802.
Courtney Stephen Martin
Hay Philip Andrew
Scopes David Ian Carter
Chu Yong
Oxford Glycoscience (UK) Ltd.
Saeed Kamal A.
Woodcock & Washburn LLP
LandOfFree
Phthalimide carboxylic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phthalimide carboxylic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phthalimide carboxylic acid derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3653910