Phthalidyl 2-(3'-trifluoromethyl-anilino)-pyridine-3-carboxylate

Details Phthalidyl 2-(3'-trifluoromethyl-anilino)-pyridine-3-carboxylate Phthalidyl 2-(3'-trifluoromethyl-anilino)-pyridine-3-carboxylate

1978-02-21

1979-09-18

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546269, C07D21355, A61K 3144

Patent

active

041683137

ABSTRACT:
A new phthalidylic eater of 2-(3'trifluoromethyl-anilino)-pyridine-3-carboxylic acid is prepared by reacting 2-(3'-trifluoromethylanilino)-pyridine-3-carboxylic acid with 3-bromophthalide and an organic base in a reaction medium comprising a solvent selected from the group consisting of acetone, dimethylformamide, dimethylacetamide and acetonitrile. The product has an antiinflammatory activity without the ulcerogenic effect that is characteristic of the corresponding acid.

REFERENCES:
patent: 3478040 (1969-11-01), Sherlock
patent: 3959272 (1976-05-01), Hoffman

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