Phthalazinone-piperidino-derivatives as PDE4 inhibitors

Details Phthalazinone-piperidino-derivatives as PDE4 inhibitors Phthalazinone-piperidino-derivatives as PDE4 inhibitors

2005-10-11

2005-10-11

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

active

06953853

ABSTRACT:
The compounds of a formula I, in which the given substituents have the meanings as given in the description, are novel effective PDE4 inhibitors

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Van der Mey, M., et al., “Novel Selective Phosphodiesterase (PDE4) Inhibitors. 4. Resolution, Absolute Configuration, and PDE4 Inhibitory Activity of cis-Tetra- and cis-Hexahydrophthalazinones”. J. Med. Chem., 45, 2526-2533, 2002.
Van der Mey, M., et al., “Novel Selective PDE4 Inhibitors. 2. Synthesis and Structure-Activity Relationships of 4-Aryl-Substituted cis-Tetra- and cis-Hexahydrophthalazinones”. J. Med. Chem., 44, 2523-2535, 2001.
Norman, Peter, “PDE4 inhibitors 2001. Patent and literature activity 2000-Sep. 2001”. Expert Opinion on Therapeutic Patents, 1, 93-111, 2002.
Van der Mey, M., et al., “Novel Selective PDE4 Inhibitors. 1. Synthesis, Structure-Activity Relationships, and Molecular Modeling of 4-(3,4-Dimethoxyphenyl)-2H-phthalazin-1-ones and Analogues”. J. Med. Chem., 2001, 44, 2511-2522.
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