Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-26
2008-08-05
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S235000, C544S237000
Reexamination Certificate
active
07407957
ABSTRACT:
A compound of formula (I):for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NRXor CRXRY; if X=NRXthen n is 1 or 2 and if X=CRXRYthen n is 1; RXis selected from the group consisting of H, optionally substituted C1-20alkyl, C5-20aryl, C3-20heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RYis selected from H, hydroxy, amino; or RXand RYmay together form a spiro-C3-7cycloalkyl or heterocyclyl group; RC1and RC2are independently selected from the group consisting of hydrogen and C1-4alkyl, or when X is CRXRY, RC1, RC2, RXand RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R1is selected from H and halo; and Het is selected from:where Y1is selected from CH and N, Y2is selected from CH and N, Y3is selected from CH, CF and N, where only one or two of Y1, Y2and Y3can be N; andwhere Q is O or S.
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Cockcroft Xiao-Ling Fan
Forte Stefano
Gomez Sylvie
Javaid Muhammad Hashim
Kerrigan Frank
Habte Kahsay T
Kudos Pharmaceuticals Limited
Maybridge Limited
Michael & Best & Friedrich LLP
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