Phthalazinone derivatives

Details Phthalazinone derivatives Phthalazinone derivatives

2006-12-19

2006-12-19

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S233000, C544S235000, C544S237000

Reexamination Certificate

active

07151102

ABSTRACT:
A method of treatment of a disease of the human or animal body mediated by PARP comprising administering to such a subject a therapeutically effective amount of a compound of formula:or an isomer, salt, solvate, chemically protected form, and prodrug thereof, wherein:A and B together represent an optionally substituted, fused aromatic ring;RCis represented by —L—RL, where L is of formula:in-line-formulae description="In-line Formulae" end="lead"?—(CH2)n1-Qn2-(CH2)n3—in-line-formulae description="In-line Formulae" end="tail"?wherein n1, n2and n3are each selected from 0, 1, 2 and 3, the sum of n1, n2and n3is 1, 2 or 3 and Q is selected from O, S, NH, C(═O) or —CR1R2—, where R1and R2are independently selected from hydrogen, halogen or optionally substituted C1-7alkyl, or may together with the carbon atom to which they are attached form a C3-7cyclic alkyl group, which may be saturated (a C3-7cycloalkyl group) or unsaturated (a C3-7cycloalkenyl group), or one of R1and R2may be attached to an atom in RLto form an unsaturated C3-7cycloalkenyl group which comprises the carbon atoms to which R1and R2are attached in Q, —(CH2)n3— (if present) and part of RL;and RLis optionally substituted C5-20aryl; andRNis selected from hydrogen, optionally substituted C1-7alkyl, C3-20heterocyclyl, and C5-20aryl, hydroxy, ether, nitro, amino, amido, thiol, thioether, sulfoxide and sulfone.

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