Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten – Producing labeled antigens
Reexamination Certificate
2004-06-14
2008-10-28
Le, Long V. (Department: 1641)
Chemistry: analytical and immunological testing
Involving producing or treating antigen or hapten
Producing labeled antigens
C436S172000, C436S800000, C435S006120, C435S007920, C530S391300, C530S409000, C540S460000, C564S152000
Reexamination Certificate
active
07442558
ABSTRACT:
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.
REFERENCES:
patent: 5049280 (1991-09-01), Raymond et al.
patent: 5820849 (1998-10-01), Schmitt-Willich et al.
patent: 6864103 (2005-03-01), Raymond et al.
patent: 7018850 (2006-03-01), Raymond et al.
patent: 2099542 (1993-07-01), None
patent: 0 578 067 (1994-01-01), None
patent: WO 92/11039 (1992-07-01), None
Blomberg, et al., “Terbium and rhodamine as labels in a homogeneous time-resolved fluorometric energy transfer assay . . . ”, Clinical Chemistry, 45(6):855-861 (1999).
Bünzli, et al., “Towards materials with planned properties: dinuclear f-f helicates and d-f non-covalent podates . . . ”, Journal of Alloys and Compounds, 249:14-24 (1997).
Chen, et al., “Lifetime- and color-tailored fluorophores in the micro- to millisecond time regime”, J. Am. Chem. Soc., 122(4):657-660 (2000).
Dickins, et al., “Synthesis, time-resolved luminescence, NMR spectroscopy, circular dichroism . . . ”, Chem. Eur. J., 5(3):1095-1105 (1999).
Dickson, et al., “Time-resolved detection of lanthanide luminescence for ultrasensitive bioanalytical assays”, J. of Photochem. and Photobiology, B: Biology, 27:3-19 (1995).
Galaup, et al., “Mono(di)nuclear europium(III) complexes of macrobi(tri)cyclic cryptands . . . ”, Helvetica Chimica Acta, 82:543-560 (1999).
Hemmilä , et al., “Development of luminescent lanthanide chelate labels for diagnostic assays”, Journal of Alloys and Compounds, 249:158-162 (1997).
de Sá , et al., “Spectroscopic properties and design of highly luminescent lanthanide coordination complexes”, Coordination Chemistry Reviews, 196:165-195 (2000).
Sabbatini, et al., “Luminescent lanthanide complexes as photochemical supramolecular devices”, Coordination Chemistry Reviews, 123:201-228 (1993).
Saha, et al., “Time-resolved fluorescence new europium chelate complex: Demonstration of highly sensitive detection of protein and DNA samples”, JACS, 115:11032-11033 (1993).
Soini, et al., “Time-resolved fluorescence of lanthanide probes and applications in biotechnology”, CRC Critical Reviews in Analytical Chemistry, 18(2):105-154 (1987).
Steemers, et al., “Water-soluble neutral calix[4]arene-lanthanide complexes: Synthesis and luminescence properties”, J. Org. Chem., 62:4229-4235 (1997).
Stenroos, et al., “Homogeneous time-resolved IL-2IL-2R· assay using fluorescence resonance energy transfer”, Cytokine, 10(7):495-499 (Jul. 1998).
Veiopoulou, et al., “Comparative study fluorescent ternary terbium complexes . . . ”, Analytica ChimicA Acta, 335:177-184 (1996).
Vicentini, et al., “Luminescence and structure of europium compounds”, Coordination Chemistry Reviews, 196:353-382 (2000).
Cohen Seth
Petoud Stephane
Raymond Kenneth N.
Xu Jide
Esker Todd W.
Haq Shafiqul
Le Long V.
Mann Jeffry S.
Morgan & Lewis & Bockius, LLP
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