Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Light application
Reexamination Certificate
2000-04-27
2003-12-16
Peffley, Michael (Department: 3739)
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Light application
C607S001000, C607S089000, C606S003000, C606S009000
Reexamination Certificate
active
06663658
ABSTRACT:
BACKGROUND OF THE INVENTION
Acne is one of the most frequently presented dermatologic conditions. To date there is no single widely accepted treatment modality although a number of approaches exist. These approaches include topical or systemic antibiotics, benzoyl peroxide gels, oral 13-cis-retinoic acid, or hormones. Acne lesions (comedones) are the result of a complex interaction between hormones (androgens) and bacteria (
Propionibacterium acnes
) in the pilosebaceous unit. Acne results when the opening of the sebaceous glands is occluded, resulting in accumulation of sebum and fatty acids produced by the bacteria through lipase breakdown of lipids. The increase in sebum results in enlargement of the glands which in turn leads to inflammation and eventually to rupture of the glandular envelop. Release of the gland contents into the dermis produces changes in the structural matrix and may result in scarring. While acne is not a life threatening condition, it frequently produces discomfort, and can be disfiguring to a subject due to scarring.
Exposure of the skin to ultraviolet radiation has been reported to result in enlargement of the sebaceous glands. This has been found in photoaging studies in hairless mice. It is also known that sun exposure results in amelioration of acne. The response to sunlight may be either due to photodynamic activity (PDT) of coproporhyrin produced by the bacteria,
Propionibacterium acnes,
or due to an effect of the sunlight to the cell differentiation and proliferation. The PDT effect would lead to destruction of the bacteria which in turn would lead to improvement of acne. In this case, short wavelength visible radiation (405-410 nm) should be equally effective in improving acne. However, there is substantial evidence that both light and antibiotics reduce the fluorescence produced by coproporphyrin, the loss of which is not always related to amelioration of the acne condition.
SUMMARY OF THE INVENTION
The present invention is directed to methods for treating acne. The methods include exposing the subject afflicted with acne to ultraviolet light having a wavelength between about 320 to about 350 nm, such that the acne is treated, e.g., inhibited, diminished, eradicated or prevented. In a preferred embodiment, the wavelength is 335 nm and is emitted by a nitrogen laser, a third harmonic of a NdYAG laser, a tunable OPO laser (Optical Parametric Oscillator), or a properly filtered mercury lamp or continuous wave lamp. Treatments can be administered over a several week period, where the subject is exposed to sequential doses of ultraviolet light to obtain beneficial effects, e.g., a reduction or elimination of the acne, e.g., eradication or diminishment of the bacteria responsible for acne, e.g.,
Propionibacterium acnes.
The present invention is also directed to methods for preventing acne. The methods include exposing the subject afflicted with acne to ultraviolet light having a wavelength between about 320 nm to about 350 nm, such that acne is prevented. In one embodiment, ultraviolet wavelengths useful in the invention are between about 325 nm to about 345 nm, preferably between about 330 to about 340 nm, more preferably between about 332 and about 337 nm, and most preferred at 335 nm.
The present invention is also directed to methods for reducing the amount or size of sebaceous glands in a subject. The methods include exposing the subject to ultraviolet light having a wavelength between about 320 and 350 nm, such that the amount or size of sebaceous glands in the subject are reduced.
The present invention is further directed to methods for treating disease states or conditions which cause or are associated with the generation of excess of sebum in sebaceous glands. The invention is also directed to methods for treating disease states or conditions which cause or are associated with the occlusion of sebaceous glands with accumulation of sebum and fatty acids produced by bacteria through lipase breakdown of lipids. These methods include exposing the subject to ultraviolet light having a wavelength between about 320 and 350 nm, such that the buildup of sebum and/or lipids in the sebaceous glands of the pilosebaceous units of the subject are reduced.
REFERENCES:
patent: 4287554 (1981-09-01), Wolff
patent: 4651739 (1987-03-01), Oseroff et al.
patent: 4930504 (1990-06-01), Diamantopoulos et al.
patent: 4945908 (1990-08-01), Schneider
patent: 5226907 (1993-07-01), Tankovich
patent: 5304170 (1994-04-01), Green
patent: 5422093 (1995-06-01), Kennedy et al.
patent: 5423803 (1995-06-01), Tankovich et al.
patent: 5425728 (1995-06-01), Tankovich
patent: 5464436 (1995-11-01), Smith
patent: 5647866 (1997-07-01), Zaias et al.
patent: 5669916 (1997-09-01), Anderson
patent: 5713845 (1998-02-01), Tankovich
patent: 5735844 (1998-04-01), Anderson et al.
patent: 5752948 (1998-05-01), Tankovich et al.
patent: 5752949 (1998-05-01), Tankovich et al.
patent: 5817089 (1998-10-01), Tankovich et al.
patent: 5925034 (1999-07-01), Buckley et al.
patent: 5955490 (1999-09-01), Kennedy et al.
patent: 6036684 (2000-03-01), Tankovich et al.
patent: 6063108 (2000-05-01), Salansky et al.
patent: 6165170 (2000-12-01), Wynne et al.
patent: 6168590 (2001-01-01), Neev
patent: 6183773 (2001-02-01), Anderson
patent: 6283956 (2001-09-01), McDaniel
patent: 6358272 (2002-03-01), Wilden
patent: 0 726 083 (1996-08-01), None
patent: WO 96/14899 (1996-05-01), None
patent: WO 96/41579 (1996-12-01), None
patent: WO 97/00098 (1997-01-01), None
patent: WO 98/33444 (1998-08-01), None
*Konig, et al. “Photodynamic Induced Inactivation of Propionibacterium Acnes Using the Photosensitizer Methylene Blue and Red Light”Dermatologische Monatsschrift,vol. 178, pp. 297-300 (1992).
*Dierickx, et al., “Photodynamic Therapy for Nevus Sebaceus with Topical Aminolevulinic Acid”Arch Dermatol,vol. 133, pp. 637-640 (1999).
*Koning, et al., “Photodynamische Aktivitat von Methylenblau”Akt. Dermatol,vol. 19, pp. 195-198 (1993).
*Konig, et al. “Photodynamically Inactivation of Propionibacterium Acnes”SPIE,vol. 3247 pp. 106-110 (1998).
*Wilkin, “Pathophysiology and Treatment”Arch Dermatol,vol. 130 pp. 359-362 (1994).
Von A. Lassus et al. Treatment of acne with selective UV-phototherapy (SUP). An open trial Dermatol Monatsschr (1993) Jun.;169(6):376-9.
Von H. Meffert et al. Phototherapy of acne vulgaris with the UVA irradiation instrument TBG 400.Dermatol Monatsschr (1986);172(2):105-6.
Von H. Meffert et al. Phototherapy of acne vulgaris with the “TuR” UV 10 body section irradiation unit., Dermatol Monatsschr (1986);172(1):9-13.
Von H. Meffert et al., Treatment of acne vulgaris with visible light, Dermatol Monatsschr (1987);173(11):678-9.
Von H. Meffert et al. Therapy of acne with visible light. Decreased irradiation time by using a blue-light high-energy lamp, Dermatol Monatsschr (1990);176(10):597-603.
Konig, et al. “Photodynamic Induced Inactivation of Propionibacterium Acnes Using the Photosensitizer Methylene Blue and Red Light”Dermatologische Monatsschrift,vol. 178, pp. 297-300 (1992).
Dierickx, et al. “Photodynamic Therapy for Nevus Sebaceus with Topical Aminolevulinic Acid”Arch Dermatol,vol. 133, pp. 637-640 (1999).
Konig, et al. “Photodynamische Aktivitat von Methylenblau”Akt. Dermatol,vol. 19, pp. 195-198 (1993).
Konig, et al. “Photodynamically Inactivation of Propionibacterium Acnes”SPIE,vol. 3247 pp. 106-110 (1998).
Wilkin, “Pathophysiology and Treatment”Arch Dermatol,vol. 130 pp. 359-362 (1994).
International Search Report, Aug. 7, 2000.
“A New Apparatus with High Radiation Energy Between 320-460 nm: Physical Description and Dermatological Applications”, Maxim F. Mutzhas, et al., The Journal of Investigative dermatology, 76:42-47, 1981.
“Ultraviolet Phototheraphy and Photochemotherapy of Acne Vulgaris”, Otto H. Mills, et al., Arch Dermatol, vol. 114, p. 221-223, Feb. 1978.
“Seasonal Variations in the Severity of Acne Vulgaris”, Michael Gfesser, et al., International Journal of Dermatology, vol. 35, No. 2, pp. 116-117, Feb. 1996.
“Phototherapy of Acne Vulgaris with Visible Light”, V. Sigurdsson, et al.,
Gillies Robert
Kollias Nikiforos
Tian Wei Dong
Nutter & McClennen & Fish LLP
Peffley Michael
The General Hospital Corporation
Vrettakos Peter
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