Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1999-04-16
2000-12-19
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514 23, 514 25, 514738, 514935, A61K 31135
Patent
active
061628336
ABSTRACT:
Aqueous solution, including at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol represented by the following formula: ##STR1## and pharmacologically acceptable salt thereof. The aqueous solution also includes at least one photostabilizer selected from the group consisting of saccharide, sugar alcohol, and polyalcohol. A content of the at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof is 0.01 to 10% (w/v) based on a volume of the aqueous solution. A content of the at least one photostabilizer is 1 to 50% (w/v) based on the volume of the aqueous solution. The content of the at least one photostabilizer is at least 10% (w/w) based on a total weight of the at least one of optically active (-)-(R)-.alpha.-((tert-butylamino)methyl)-2-chloro-4-hydroxybenzyl alcohol and pharmacologically acceptable salt thereof. Method of making a stabilized aqueous solution.
REFERENCES:
Copy of the Chemical Abstract No. 125:49312s, vol. 125, No. 5, 1996, p. 150.
Copy of the Chemical Abstract No. 123:93355r, vol. 123, 1995, p. 707.
Copy of the Chemical Abstract No. 109:11744r, vol. 109, 1988, p. 337
Ohki et al., Encyclopedic Dictionary of Chemistry, pp. 113, 1338 and 1969 (1989), with English language translations of the terms "alcohol", "Polyhydric alcohol, and Phenolic hydroxy group".
Remington's Pharmaceutical Sciences, pp. 1235, 1254, 1255, and 1264 (1975).
Ito Yasuo
Kato Hideo
Koshinaka Eiichi
Matsuo Kazuya
Yamazaki Masahiro
Cook Rebecca
Hokuriku Seiyaku Co. Ltd.
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