Photosensor with multiple light sources

Details Photosensor with multiple light sources Photosensor with multiple light sources

1995-11-29

1998-06-30

Nasser, Robert L.

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

600316, 600323, 600330, 356 41, A61B 500

Patent

active

057725870

ABSTRACT:
The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.

REFERENCES:
patent: 4840485 (1989-06-01), Gratton
patent: 4854699 (1989-08-01), Edgar, Jr.
patent: 4972331 (1990-11-01), Chance
patent: 5032024 (1991-07-01), Cope
patent: 5057695 (1991-10-01), Hirao et al.
patent: 5122974 (1992-06-01), Chance
patent: 5167230 (1992-12-01), Chance
patent: 5187672 (1993-02-01), Chance et al.
patent: 5188108 (1993-02-01), Secker
patent: 5209231 (1993-05-01), Cote et al.
patent: 5212386 (1993-05-01), Gratton et al.
patent: 5213105 (1993-05-01), Gratton et al.
patent: 5243983 (1993-09-01), Tarr et al.
patent: 5267715 (1993-12-01), Yang et al.
patent: 5331958 (1994-07-01), Oppenheimer
patent: 5348003 (1994-09-01), Caro
patent: 5402778 (1995-04-01), Chance
patent: 5515847 (1996-05-01), Braig et al.
patent: 5517987 (1996-05-01), Tsuchiya
patent: 5553614 (1996-09-01), Chance
patent: 5564417 (1996-10-01), Chance
Article entitled: "Time-Resolved Spectroscopy of the Human Forearm" by Ferrari et al.--J. Photochem. Photobiol. B: Biol., 16 (1992) 141-153.
Article entitled: "Tissue Characterization and Imaging Using Photon Density Waves" by Svaasand et al.--Optical Engineering, Feb., 1993, vol. 32 No. 2, pp. 258-265.
Article by J.R. Lakowicz et al. entitled Frequency-domain fluorescence spectroscopy, a new method for the resolution of complex fluorescence emission, from Trends in Analytical Chemistry Nov., 1986 pp. 257-263.
Article by Patterson et al. by Applied Optics, vol. 30, No. 31, pp. 4474-4476 entitled: "Frequency-Domain Reflectance for the Determination of the Scattering and Absorption Properties of Tissue", 1 Nov., 1991.
Article by Patterson et al. by Applied Optics, vol. 28, No. 12, pp. 2331-2336 entitled: "Time Resolved Reflectance and Transmittance for the Non-Invasive Measurement of Tissue Optical Properties", 15 Jun., 1989.

Affiliated with

Also associated with

Rating

Photosensor with multiple light sources does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Photosensor with multiple light sources, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photosensor with multiple light sources will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1853647