Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2005-12-20
2005-12-20
Swartz, Rodney P (Department: 1645)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C424S009362, C424S009610, C424S168100, C424S180100, C424S182100, C424S248100, C435S863000, C435S253100, C540S145000
Reexamination Certificate
active
06977075
ABSTRACT:
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.
REFERENCES:
patent: 5091385 (1992-02-01), Gulliya et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5389378 (1995-02-01), Madden
patent: 5489590 (1996-02-01), Gulliya et al.
patent: 5512675 (1996-04-01), Tang et al.
Soukos et al. (1998) Antimicrob. Agents Chemother. 42(10): p. 2595-2601.
Hryhorenko et al. (1998) Immunopharacology 40:231-240.
Korbelik et al. (1991) Cancer Res 51:2251-2255.
Korbelik et al. (1991) Br J Cancer 64(3):508-512.
Elmer et al. (1987) J Surg Oncol 34:113-119.
Brassuer et al. (1999) Photochem Photobiol 69(3):345-352.
de Vries et al. (1999) J Pharmacol Exp Ther 289(1)528-534.
Hamblin et al. (2000) Photochem Photobiol 72(4):533-540.
Hamblin & Newman (1994) J Photochem Photobiol B 23:3-8.
Korbelik et al. (1993) Photochem Photobiol 58(5):670-675.
Warren and Body, Ch. 3,Tuberculosis, Eds. MD Rossman and RR MacGregor, 1995, McGraw-Hill, New York.
http://www.sanger.ac.uk/Info/Press/020301.shtml.
Besra and Chatterjee, Ch. 20,Tuberculosis: Pathogenesis, Protection, and Control, Ed. BR Bloom, 1994, American society for Microbiology, Washington, D.C.
Andersen and Brennan, Ch. 21,Tuberculosis: Pathogenesis, Protection, and Control, Ed. BR Bloom, 1994, American society for Microbiology, Washington, D.C.
Bloom and Fine, Ch. 31,Tuberculosis: Pathogenesis, Protection, and Control, Ed. BR Bloom, 1994, American society for Microbiology, Washington, D.C.
Schein and Huebner, Ch. 5,Tuberculosis, Eds. MD Rossman and RR MacGregor, 1995, McGraw-Hill, New York.
Ratledge, Ch. 5,The Biology of Mycobacteria, vol. 1 Ed. C Ratledge and J Stanford, 1982, Academic Press, London.
Winder, Ch. 8,The Biology of Mycobacteria, vol. 1 Ed. C Ratledge and J Stanford, 1982, Academic Press, London.
http://www/hc-sc.gc.ca/pphb-dgspsp/msds-ftss/msds103e.html.
Malik et al. “New Trends in Photobiology (Invited Review) Bactericidal Effects of Photoactivated Porphyrins-An Alternative Approach to Antimicrobial Drugs” Journal of Photochemistry and Photobiology, B: Biology, 5 (1990) 281-293.
Soukos, N. et al. “Targeted Antimicrobial Photochemotherapy” Antimicrobial Agents and Chemotherapy, vol. 42, Oct. 1998 2595-2601.
Gross et al., (1958) “The heat precipitation of collagen from neutral salt solutions: Some rate-regulating factors” J. of Biol. Chem. vol. 233, Nos. 1-3, pp. 355-360.
Ridley et al. (1983) “Experimental epithelioid cell granulomas tubercle formation and immunological competence: an ultrastructural analysis” J of Pathol. vol. 141, No. 1, pp. 97-112.
Gross Jerome
Hasan Tayyaba
Nau Gerard J.
Edwards & Angell LLP
Leahy Amy M.
Swartz Rodney P
The General Hospital Corporation
LandOfFree
Photosensitizer conjugates for targeting intracellular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Photosensitizer conjugates for targeting intracellular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photosensitizer conjugates for targeting intracellular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3497756