Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-30
2009-06-23
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07550587
ABSTRACT:
The invention relates to medicine and concerns a photosensitizer for detecting and curing tumors. The inventive photosensitizer is embodied in the form of a composition containing chlorin in the form of salt and alkali metals. The chlorin is composed of 80-90% of chlorin e6, 5-20 of purpurin 5 and the rest being purpurin 18-chlorin p6. Said photosensitizer is produced by extractingSpirulinabiomass with the aid of acetone. Afterwards said biomass is exposed to acid treatment, neutralization, hydrolysis, extraction of pheophorbide a, dissolution in acetone, addition of a strong base, neutralization and reprecipitation of chlorin e6.
REFERENCES:
patent: 5216012 (1993-06-01), Morgan et al.
patent: 5330741 (1994-07-01), Smith et al.
patent: 2054476 (1994-07-01), None
patent: 2152790 (2002-07-01), None
Derwent Abstract of Patent RU 2 054 476 C1,Derwent Publications Ltd., Accession No. 1996-463143, 1996.
Fischer, H. et al., “Chlorophyll. LXXXVII. Partial Oxidation of Several Chlorophyll Derivatives”,Chemical Abstracts Service, Accession No. 1939-44413, 1939.
Hynninen, P., “Chlorophylls, IV. Preparartion and Purification of Some Derivatives of Chlorophylls a and b”,ACTA Chemica Scandinavica, vol. 27, No. 5, pp. 1771-1780, 1973.
Iwai, K. et al., “Therapeutic Effect of Chlorin e6 Sodium as a New Photosensitizing Agent in the Photodynamic Therapy of Mouse Tumors”,Journal of Clinical Biochemistry and Nutrition, vol. 6, No. 2, pp. 117-125, 1989.
Reshetnickov, A. et al., “Novel Drug Form of Chlorin e6”,Proceedings of Spie-the International Society for Optical Engineering, 3909(Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamis Therapy IX), pp. 124-130, 2000.
Supplementary European Search Report dated Oct. 13, 2005.
Abakumova Olga Yurievna
Gradjushko Alexandr Tikhonovich
Ivanov Andrei Valentinovich
Karmenyan Artashes Vacheevich
Kemov Jury Viktorovich
Brinks Hofer Gilson & Lione
Nichols G. Peter
Obschestvo S Ogranichennoi Otvetstvennostiju “Rada-Pharma
Ward Paul V.
Wilson James O.
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