Photosensitisers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S410000, C534S015000, C540S145000

Reexamination Certificate

active

10393783

ABSTRACT:
A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a photosensitising chromophoric system, a sulphonamido functionality and a carboxy functionality. The compounds used in the present invention are photosensitisers in PDT in vivo, and show phototoxic activity in vitro. The compounds are used to treat pre-cancerous conditions, cancer, ophthalmological disease, vascular problems, arteriosclerosis and restenosis and autoimmune diseases, skin diseases and other benign conditions, and for anti-microbial treatments.

REFERENCES:
patent: 5587463 (1996-12-01), Sessler et al.
patent: 0 322 795 (1995-09-01), None
patent: 0322795 (1995-09-01), None
patent: 64-68352 (1989-03-01), None
patent: 64-68696 (1989-03-01), None
patent: 64-70096 (1989-03-01), None
patent: 1-319702 (1989-12-01), None
patent: 4-322425 (1992-11-01), None
patent: WO98/30242 (1998-07-01), None
Allen et al., “Photodynamic Therapy . . . ”, Photochemistry and Photobiology (1999), 70(4), 512-23.
Brasseur et al, “Receptor mediated targeting of phthalocyanines . . . ”, Photochemistry and Photobiology (1999) 69(3), 345-52.
Griffiths, et al., “Some observations on the synthesis of polysubstituted zinc phthalocyanine . . . ”, Dyes and Pigments (1997), 33(1), 65-78.
Mellish, K.J.; Vernon, D.I.; Schofield, J.; Griffiths, J.; Brown, S.B. Structure Activity Relationships of a Series of Tetra-Substituted Zinc Phthalocyanines Sep. 8, 1999. Centre for Photobiology and Photodynamic Therapy, University of Leeds, Leeds, United Kingdom.
“Photobleaching of Sensitisers Used in Photodynamic Therapy”, Bonnet et al., Tetrahedron 57 (2001) 9513-9547.
“Tissue-Localazing Properties of Some Photosensitizers Studied byin vivoFluroscence Imaging”, Van Leengoed et al., Journal of Photoch. And Photobiol., B. biology 6 (1990), 111-119.
“ Investigation of Cross-resistance to a Range of Photosensitizers, Hyperthermia and UV Light in Two Radiation-induced Fibrosarcoma Cell Strains Resistant to Photodynamic TherapyIn Vitro”, Oct. 17, 2000.
Mayhew et al., Photochemistry and Phtobiology, 2001, 73(1): 39-46.
“Effect of Light Fluence rate on Mammalian Celss Photosensitization by Chloroaluminium Phthalocyanine Tetrasulphonate”, Ben-Hur et al., Inter. Journal of Radiation Biology, Sep. 26, 1986, vol. 51, No. 3, 467-476.
Patent Abstract of Japan vol. 014, No. 128 (Mar. 9, 1990) & JP 01-319702 (Dec. 26, 1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Photosensitisers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Photosensitisers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photosensitisers will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3901921

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.