Surgery – Blood drawn and replaced or treated and returned to body – Constituent removed from blood and remainder returned to body
Reexamination Certificate
2005-07-12
2005-07-12
Bianco, Patricia (Department: 3762)
Surgery
Blood drawn and replaced or treated and returned to body
Constituent removed from blood and remainder returned to body
C604S004010, C604S006140
Reexamination Certificate
active
06916303
ABSTRACT:
A method and an apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method includes adding electron donors such as amino acids, saccharides, alcohols, and/or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.
REFERENCES:
patent: 4578056 (1986-03-01), King et al.
patent: 5429594 (1995-07-01), Castle
patent: 5476764 (1995-12-01), Bitensky
patent: 4-59735 (1992-02-01), None
Of Sakai et al. “Physical Properties of Hemoglobin Vesicles as Red Cell Substitutes” (Biotechnol. Prog. 1996, 12, 119-125).
Djordjevich and Miller, Lipid Encapsulated Hemoglobin as a Synthetic Erythrocyte, Federation Proceedings vol. 36, 1977.
Tsuchida ed., Perspectives of Blood Substitutes, Blood Substitutes—Present and Future Perspectives, Elsevier, Amsterdam, 1-14, 1998.
Sakai et al., Suppression of Methemoglobin Formation by Glutathione in a Concentrated Hemoglobin Solution and in a Hemoglobin-Vesicle, Bull. Chem. Soc., 67, 1120-1125, 1994.
Takeoka et al., Reduction of Methemoglobin via Electron Transfer across the Bilayer Membrane of Hb Vesicles, Bull. Chem. Soc. Jpn., 70, 1171-1178, 1997.
Vorkink et al., Photoreductionof Horse Heart Cytochrome c, Photochem. Photobiol. 19, 205-215, 1974.
Kitagawa et al., Quaternary Structure-induced Photoreduction of Haem of Haemoglobin, Nature, 281, 503-504, 1979.
Kitagawa et al., Resonance Raman Study of Subunit Assembly Dependent Photoreduction of Heme of Extracellular Giant Hemoglobin, J. Am. Chem. Soc. 106, 1860-1862, 1984.
Morikis et al., Resonance Raman Studies of Iron Spin and Axial Coordination in Distal Pocket Mutants of Ferric Myoglobin, J. Biol. Chem. 265, 12143-12145, 1990.
Saga et al., Resonance Raman studies of oriented chromophores: Metmyoglobin single crystals, J. Chem. Phys. 90, 3015-3032, 1989.
Gu et al., Photoreduction of Heme Proteins: Spectroscopic Studies and Cross-Section Measurements, J. Am. Chem. Soc., 115, 4993-5004, 1993.
Pierre et al., One-Electron Photoreduction of Bacterial Cytochrome P-450 by Ultraviolet Light, Eur. J. BioChem. 124, 533-537, 1982.
Bazin et al., One-Electron Photoreduction of Bacterial Cytochrome P-450 by Ultraviolet Light, Eur. J. BioChem. 124, 539-544, 1982.
Yubisui et al., Stopped Flow Studies on the Nonenzymatic Reduction of Methemoglobin by Reduced Flavin Mononucleotide, J. Biol. Chem. 255, 11694-11697, 1980.
Everse, Photochemical Reductionof Methemoglobin and Methemoglobin Derivatives, Methods Enzymol. 231, 524-536, 1994.
Sakai et al., Physical Properties of Hemoglobin Vesicles as Red Cell Substitutes, Biotechnol. Progress, 12, 119-125, 1996.
Sakai et al., Surface Modification of Hemoblogin Vesicles with Poly (ethylene glycol) and Effects onAggregation, Viscosity, and Blood Flow during 90 % Exchange Transfusion in Anesthetized Rats, Bioconjugate Chem. 8, 23-30, 1997.
Ogata et al., The development of the Neo Red Cells (NRC) with enzymatic reduction system of the methemoglobin, Artificial Blood, 2, 62-66, 1994.
Sakai Hiromi et al., Photoreduction of methemoglobin by irradiation in the near-ultraviolet region, Biochemistry vol. 39, No. 47, Nov. 28, 2000, pp. 14595-14602, XP002271500, ISSN: 0006-2960.
Database WPI, Section PQ, Week 198912, Derwnt Publications Ltd., London, XP002271501, Sep. 23, 1988 and SU 1424 851 A (Transplant Artifici) (abstract).
Database WPI, Section PQ, Week 198615, Derwent Publications Ltd., London, XP002271502 (abstract) and US 4,578,056 A (EXTS) Mar. 25, 1986.
Onuma Hiroto
Sakai Hiromi
Takeoka Shinji
Tsuchida Eishun
Bianco Patricia
Japan Science and Technology Corporation
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
LandOfFree
Photoreduction method for hemoglobin-vesicle does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Photoreduction method for hemoglobin-vesicle, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photoreduction method for hemoglobin-vesicle will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3421398