Chemistry of inorganic compounds – Nitrogen or compound thereof – Binary compound
Reexamination Certificate
2005-02-17
2011-10-11
Mayes, Melvin (Department: 1732)
Chemistry of inorganic compounds
Nitrogen or compound thereof
Binary compound
C423S351000, C423S063000, C424S617000, C436S063000, C530S412000
Reexamination Certificate
active
08034314
ABSTRACT:
The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.
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Israelson Adrian
Shoshan-Bar-Matz Varda
Gregorio Guinever
Mayes Melvin
McCarthy Kevin D.
Roach Brown McCarthy & Gruber P.C.
The National Institute for Biotechnology in the Negev Ltd.
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