Photoprotein conjugates and methods of use thereof

Details Photoprotein conjugates and methods of use thereof Photoprotein conjugates and methods of use thereof

1994-08-22

1996-01-23

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 71, 536 266, C12Q 170, C12Q 168, G01N 3353, C07H 1904

Patent

active

054864550

ABSTRACT:
The present invention encompasses a method of synthesis of conjugates of photoproteins that retain all or a substantial portion of the luminescent activity of underivatized photoprotein. According to the present invention photoproteins may be conjugated with a variety of binding including streptavidin/avidin, glyco-proteins, lectins, hormones, antigens, drugs, antibodies and antigen binding fragments thereof, or any other selectively bindable reagent by chemical crosslinking means. The present invention also encompasses conjugates produced by this method, and methods of use of such conjugates.

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