Photoprotective lipophilic antioxidant compounds and their use t

Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations

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424 60, 424400, 424401, A61K 742, A61K 744, A61K 700

Patent

active

057470103

ABSTRACT:
The present invention relates to a method of protecting skin from the oxidative effects of ultraviolet A radiation including UVA-induced lipid peroxidation. The method comprises topically applying to the skin an effective amount of a photoprotective composition that contains a lipophilic antioxidant that does not have appreciable absorbance near wavelengths of 320-380 nm.

REFERENCES:
patent: 4847072 (1989-07-01), Bissett et al.
patent: 5279817 (1994-01-01), Franco
patent: 5445815 (1995-08-01), Siegfried
Bissett, D.L., et al., Photoprotective Effect of Superoxide Scavenging Antioxidants Against Ultraviolet Radiation-Induced Chronic Skin Damage In The Hairless Mouse, Photodermatol Photoimmunol Photomed 1990: 7: pp. 56-62.
Kligman, L.H., et al., Biochemical Changes in Hairless Mouse Skin Collagen After Chronic Exposure to Ultraviolet-A Radiation, Photochemistry and Photobiology vol. 54, No. 2, pp. 233-237, 1991.
Boyer, B., et al., UVA-and UVB-Induced Changes In Collagen And Fibronectin Biosynthesis in the Skin of Hairless Mice, J. Photochem. Photobiol. B: Biol., 14 (1992) pp. 247-159.
Bose, B. et al., Effect of UV-A on the Linolenic Acid Micelles, Radiation Research 133, pp. 340-344 (1993).
Zheng, P., et al., UVA-Induced Ultrastructural Changes in Hairless Mouse Skin: A Comparison of UVB-Induced Damage, The Society for Invesntigative Dermatology, Inc. 1993, pp. 194-199.
Longas, M., et al., Dietary Vitamin E Reverses the Effects of Ultraviolet Light Irradiation on Rat Skin Glycosaminoglycans, Biochimica et Biophysica Acta, 1156 (1993), pp. 239-244.
Bissett, D.L., et al., Wavelength Dependence of Histological, Physical, and Visible Changes in Chronically UV-Irradiated Hairless Mouse Skin, Photochemistry and Photobiology, vol. 50, No. 6, pp. 763-769, 1989.
Shaath, Nadim, Encyclopedia of UV Absorbers of Sunscreen Products, Cosmetics & Toiletries, Mar. 1987, vol. 102, No. 3, pp. 21-23.

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