Photopheresis treatment of leukocytes

Surgery – Blood drawn and replaced or treated and returned to body

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A61M 3700

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059848871

ABSTRACT:
A method of treating infections of mononuclear blood cells, other than retroviral infections, is disclosed. A method of modulating the function of monocytes is also disclosed. The method involves the treatment of a patient's blood with a photoactivatable compound followed by ultra violet light-activation of the photoactivatable compound. The blood treated as such is returned to the patient in a process known as extracorporeal photopheresis. Monocyte function is modulated by this treatment.

REFERENCES:
patent: 298279 (1884-10-01), Lee et al.
patent: 298567 (1884-11-01), Morris
patent: D299531 (1989-01-01), Troutner et al.
patent: 299953 (1884-02-01), King et al.
patent: 4196281 (1980-04-01), Hearst et al.
patent: 4321919 (1982-03-01), Edelson
patent: 4398906 (1983-08-01), Edelson
patent: 4428744 (1984-01-01), Edelson
patent: 4452811 (1984-06-01), della Ville
patent: 4464166 (1984-08-01), Edelson
patent: 4464354 (1984-08-01), Bisagni et al.
patent: 4465691 (1984-08-01), Bisagni et al.
patent: 4568328 (1986-02-01), King
patent: 4573960 (1986-03-01), Goss
patent: 4573961 (1986-03-01), King
patent: 4573962 (1986-03-01), Troutner
patent: 4578056 (1986-03-01), King et al.
patent: 4596547 (1986-06-01), Troutner
patent: 4612007 (1986-09-01), Edelson
patent: 4613322 (1986-09-01), Edelson
patent: 4623328 (1986-11-01), Hartranft
patent: 4643710 (1987-02-01), Troutner
patent: 4681568 (1987-07-01), Troutner
patent: 4683889 (1987-08-01), Edelson
patent: 4684521 (1987-08-01), Wdelson
patent: 4687464 (1987-08-01), Troutner
patent: 4692138 (1987-09-01), Troutner et al.
patent: 4693981 (1987-09-01), Wiesehahn et al.
patent: 4705498 (1987-11-01), Goss
patent: 4708715 (1987-11-01), Troutner et al.
patent: 4726949 (1988-02-01), Miripol et al.
patent: 4727027 (1988-02-01), Wiesehahn et al.
patent: 4737140 (1988-04-01), Lee et al.
patent: 4748120 (1988-05-01), Wiesehahn
patent: 4838852 (1989-06-01), Edelson et al.
patent: 4866282 (1989-09-01), Miripol et al.
patent: 4897789 (1990-01-01), King et al.
patent: 4921473 (1990-05-01), Lee et al.
patent: 4952812 (1990-08-01), Miripol et al.
patent: 4960408 (1990-10-01), Klainer et al.
patent: 4999375 (1991-03-01), Bachynsky et al.
patent: 5030200 (1991-07-01), Judy et al.
patent: 5176921 (1993-01-01), Wiesehahn et al.
patent: 5216176 (1993-06-01), Heindel et al.
patent: 5288605 (1994-02-01), Lin et al.
patent: 5356929 (1994-10-01), Heindel et al.
patent: 5360734 (1994-11-01), Cgaonab et al.
patent: 5399719 (1995-03-01), Wollowitz et al.
patent: 5459030 (1995-10-01), Lin et al.
patent: 5482828 (1996-01-01), Lin et al.
patent: 5651993 (1997-07-01), Edelson et al.
Richard Edelson et al. "Treatment of Cutaneous T-cell Lymphoma By Extracorporeal Photochemotherapy" New England Journal of Medicine 316:297-303 (Feb. 5, 1987).
Marglis-Nunno et al."Elimination of Potential Mutagenicity in Plantlet Concentrates that are virally Inactivate with Psoralens and Ultraviolet A Light" Transformation 1985:pp. 855-862.
Hoofnagle et al. Treatment of chronic Non-A, Non-B Hepatitis with Recombinant Human Alpha interferon New England Journal of Medicine vol. 315 No. 25 pp. 1575-1578.
Davis et al. "Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa" New England Journal of Medicine vol. 321 No. 22 pp. 1501-1505.
DiBisceglie et al. "Recombinant Interferon Alfa Therapy for Chronic Hepatitis C" New England Journal of Medicine vol. 321 No. 22 pp. 1506-1510.
Farci et al "A Long-term Study of Hepitatis C Virus Replication in non-A, Non-B Hepatitis" New England Journal of Medicine vol. 325 No. 2 pp. 98-103.
Shindo et al. "Decrease in Serum Hepatitis C Viral RNA during Alpha-Interferon Therapy for Chronic Hepatitis C" Annals of Internal Medicine vol. 115 No. 9 pp. 701-704.
"High Dose Interferon Alfa-2A for the Treatment of Chronic Hepatitis C" The Annals of Pharmacotherapy 1994 Mar. vol. 28 pp. 341-342.
M. Gomez-Rubio et al. "Prolonged Treatment (18 months) of Chronic Hepatitis C with Recombinant .alpha.-Interferon in comparison with a control group" Journal of Hepatology, 1990:11:S63-S67.
Saez-Royuela et al. "High Doses of Recombinant .alpha.-Interferon or .gamma.-Interferon for Chronic Hepatitis C: A Randomized, Controlled Trial" Hepatology 1991; 13:No. 2 327-331.
Nakano et al. "Comparative Study of Clinical, Histological, and Immunologics Responses to Interferon Therapy in Type Non-A, Non-B, and Type B Chronic Hepatitis" The American Journal of Gastroenterology vol. 85; No. 1.1990.
Haysahi et al. "Improvement of Serum Aminotransferase Levels after Phlebotomy in Patients with chronic Active Hepatitis C and Excess Hepatic Iron" The American Journal of Gastroenterology vol. 89; No. 7.1994 pp. 986-988.
Ljunggren et al. "Plasma Levels of 8 Methoxypsoralen Determined by High-Pressure Liquid Chromatography in Psoriatic Patients Ingesting Drug from Two Manufacturers" The Journal of Investigative Dermatology, vol. 74, No. 1 pp. 59-62.
Christer T. Jansen et al. "Inter-and Intraindividual Variations in Serum Methoxsalen Levels During Repeated Oral Exposure" Therapeutic Research vol. 33, No. 2 pp. 258-264.
Michael J. Clemens et al. "Regulation of Cell Proliferation and Differentiation by Interferons" Bronchena J. (1985) 226, 345-360.
Witter et al. "Efffects of Prednisone, Aspirin, and Acetaminophen on an in vivo biologic response to interferon in humans" Clin Pharmacol Ther Aug. 1988 pp. 239-243.
Alain H. Rook, et al. "Combined Therapy for Sezary Syndrome With Extracorporeal Photochemotherapy and Low-Dose Interferon Alfa Therapy" Arch Dermatol. 1991;127: pp. 1535-1540.
Alain H. Rook, et al. "Treatment of Automimmune Disease with Extracorporeal Photochemotherapy: Pemphigus Vulgaris" The Yale Journal of Biology and Medicine 62 (1989). 647-652.
Barr et al. "Immunomodulation with photopheresis: Clinical Results of the Multi-Center Cardiac Transplantation Study" Study supported by Therakos, A Johnson & Johnson Company.
Costanzo-Nordin et al. "Successful Treatment of Heart Transplant Rejection with Photopheresis" Transplantation vol. 53, 808-815, No. 4 Apr. 1992.
Meiser et al., Reduction of the Incidence of rejection by Adjunct Immunosuppression with Photochemotherapy After Heart Transplantation Transplantation vol. 57 563-566 No. 4 Feb. 1994.
Vowels et al. "Extracorporeal Photochemotherapy Induces the Production of Tumor Necrosis Factor-.alpha. by Monocytes: Implications for the Treatment of Cutaneous T-ell Lymphoma and Systemic Sclerosis" The Journal of Investigative Dermatology, Inc. vol. 98:686-692, 1992.
Gil et al. Hepatic and Extrahepatic HCV RNA Strands in Chronic Hepatitis C: Different Patterns of Respons to Interferon Treatment Hepatology 1993; 18, 1050-1054.
Qian et al. "Replication of hepatitis C Virus in peripheral blood mononuclear cells" Journal of Hepatology 1992;16:380-383.
Elcanor C. Mandoza et al. "Decreased Phorbol Myristate Acetate-Induced Release of Tumor Necrosis Factor-.alpha. and Interleukin-1.beta. from Peripheral Blood Monocytes of Patients Chronically Infected with Hepatitis C Virus" Journal of Infectious Disease 1996 vol. 174 pp. 42-44.
Zignego et al. "Infection of peripheral mononuclear blood cells by hepatitis C Virus" Journal of Hepathology, 1992;15:382-386.
"Mutsunori Shirai et al. "Introduction of Cytotoxic T Cells to a Cross-Reactive Epitope in the Hepatitis C. Virus Nonstructural RNA polymerase-Like Protein" Journal of Virology, Jul. 1992;pp. 4098-4106.
Amy J. Weiner et al. "Evidence for immune selection of hepatitis C virus (HCV) putative enveolpe glycoprotein variants: Potential role in chronic HCV infections" Proc. Natl. Acad. Sci. USA vol. 89 pp. 3468-3472.
Shimizu et al. "Early events in hepatitis C. Virus infection of chimpanzees" Proc. Natl. Acad. Sci. USA 87 pp. 6441-6444.
J. A. Garson et al. "Enhanced detection by PCR of hepatitis C virus RNA" The Lancet Oct. 6, 1990 p. 878.
P. Simmonds et al. "Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region" Journal of General Virology (1993). 74 2391-2399.
Houghton et al. "Monecular Biology of the Hepatitis C Virues: Implications

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