Photonic molecular probe

Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...

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600316, 356364, A61B 500

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058714421

ABSTRACT:
An opto-electronic device utilizes a band of polychromatic light for quantitative analysis of a target molecule within a mixed specimen. A movable polarizer produces a segmented band of partially polarized polychromatic light from the band of partially polarized polychromatic light. A specimen cell adapted for receiving the mixed specimen transports the segmented band of partially polarized polychromatic light to the mixed specimen. A movable polarizing analyzer is optically coupled to the segmented band of partially polarized polychromatic light exiting the mixed specimen. The segmented band of partially polarized polychromatic light before entering the mixed specimen is compared with the segmented band of partially polarized polychromatic light after exiting the mixed specimen. The movable polarizer is synchronized with the movable polarizing analyzer. Additionally a frequency filter can be optically coupled to the movable polarizer, where the frequency filter produces a beam of single frequency ellipitically polarized light from the band of partially polarized polychromatic light such that the segmented band of partially polarized polychromatic light is a segmented band of ellipitically polarized light.

REFERENCES:
patent: 3958560 (1976-05-01), March
patent: 4223680 (1980-09-01), Jobsis
patent: 4266554 (1981-05-01), Hamaguri
patent: 4281645 (1981-08-01), Jobsis
patent: 4714080 (1987-12-01), Edgar, Jr. et al.
patent: 4882492 (1989-11-01), Schlager
patent: 4901728 (1990-02-01), Hutchison
patent: 4975581 (1990-12-01), Robinson et al.
patent: 5009230 (1991-04-01), Hutchinson
patent: 5028787 (1991-07-01), Rosenthal et al.
patent: 5068536 (1991-11-01), Rosenthal
patent: 5077476 (1991-12-01), Rosenthal
patent: 5086229 (1992-02-01), Rosenthal et al.
patent: 5115133 (1992-05-01), Knudson et al.
patent: 5146091 (1992-09-01), Knudson
patent: 5209231 (1993-05-01), Cote et al.
patent: 5267152 (1993-11-01), Yang et al.
patent: 5277181 (1994-01-01), Mendelson et al.
patent: 5313941 (1994-05-01), Braig et al.
patent: 5362966 (1994-11-01), Rosenthal et al.
patent: 5370114 (1994-12-01), Wong et al.
patent: 5383452 (1995-01-01), Buchert
patent: 5398681 (1995-03-01), Kupershmidt
patent: 5452717 (1995-09-01), Branigan et al.
patent: 5459317 (1995-10-01), Small et al.
patent: 5492118 (1996-02-01), Gratton et al.
patent: 5515847 (1996-05-01), Braig et al.
patent: 5519208 (1996-05-01), Esparza et al.
patent: 5553616 (1996-09-01), Ham et al.
patent: 5574283 (1996-11-01), Quintana
patent: 5687721 (1997-11-01), Kuhls
PCT International Publication No. WO 94/05984, Publication Date-Mar. 17, 1994, Internationa Application No. PCT/US93/08319, International Filing Date Sep. 3, 1993, Inventor-Milton R. Kaplan.
Flock et al., onte Carlo Modeling of Light Propagation in Highly Scattering Tissues-II: Comparison with Measurements in Phantom IEEE,, vol. 36, No. 12, Dec. 1989 pp. 1169-1173.
Taitelbaum et al, Approximate Theory of Photon Migration in a Two-Layer Medium, Applied Optics vol. 28, No, 12, 15 Jun. 1989, pp. 2245-2247.
Marbach et al, Comparison of Multiivariate Calibration with PCR and PLS for Glucose Using Infrared Spectra of Human Whole Blood, SpIE vol. 1145 Fourier Transform Spectroscopy (1989), pp. 437-438.
Ward, et al, Quantitative Infrared Spectroscopy of Glucose in Blood Using Partial Least-Squares Analyses, SPIE vol. 1145 Fourier Transform Spectroscopy (1989), pp. 607-608.
Kellner, Development and Performance of a Novel Ir-Atr-Based Glucose Sensor System, SPIE vol. 1145 Fourier Transform Spectroscopy (1989), pp. 134-137.
Schmidt et al, Multilayer Model of Proton Diffusion in Skin,. Soc. Am. A. vol. 7, No. 11/Nov. 1990, pp. 2141-2153.
Dayan, et al, Photon Migration in a Two-Layer Turbid Medium a Diffusion Analysis, Journal of Modern Optics 1992, vol. 39, No. 7, pp. 1567-1582.
Ward et al, Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy Applied Spectroscopy, vol. 46, No. 6, 1992, pp. 959-965.
Haaland et al, Reagentless Near-Infrared Determination of Glucose in Whole Blood Using Multivariate Calibration, Applied Spectroscopy, vol. 46, No.10, 1992, pp. 1572-1578.
Marbach et al, Noninvasive Blood Glucose Assay by Near-Infrared Diffuse Reflectance Spectroscopy of the Human Inner Lip, Applied Spectroscopy, vol. 47, No. 7, 1993, pp. 875-881.
Zhou et al, Sensitive Detection of Optical Rotation in Liquids by Reflection Polarimetry, American Institute of Physics,, Rev. Sci Instrum 64(10), Oct. 1993, p. 28012807.
Heise et al, Effect of Data Pretreatment on the Noninvasive Blood Glucose Measurement by Diffuse Reflectance NIR Spectroscopy, SPIE, vol. 2089, Jul. 1994 pp. 114-115.
Maier, et al, Possible Correlation Between Blood Glucose Concentration and the Reduced Scattering Oefficient of Tissues in the Near Infrared, Optical Society of American Vol. 19, No. 24/Dec. 15, 1994, pp. 2062-2064.
Aronson, Boundary Conditions for Diffusion of Light, Optical Society of America, vol. 12.backslash.No. 11/Nov. 1995, pp. 2533-2540.
Bigio et al, Noninvasive Identification of Bladder Cancer with Sub-Surface Backscattered Light SPIE, vol. 2135, 0-8194-1430-Jan. 1994, pp. 26-35 Jan. 1994.
Kohl, et al, Glucose Induced Changes in Scattering and Light Transport in Tissue Simulating Phantoms SPIE, vol. 2839, 0-8194--1736-X95, pp. 780-788. 1995.
Qu et al, The Effect of Physiological Factors and Other Analytes on the Determination of Glucose Concentration in Vivo by Optical Absorption and Scattering Measurements, SPIE, vol. 2679,8194--2053-0/96, pp. 236-242. 1995.
Chung et al, Simultaneous Measurements of Glucose, Glutamine, Ammonia, Lactate, and Glutamate in Aqueous Solutions by Near-Infrared Spectroscopy, Applied Spectroscopy, Vol. 50, No. 2, 1996, pp. 270-276.
Nafie, Vibrational Optical Activity, Focal Point, vol. 50, No. 5, 1996, pp. 14A-26A.
Polavarapu et al, Measurement of Vibrational Circular Dichroism Below -600 cm .sup.=1; Progress Towards Meeting the Challenge, Applied Spectroscopy, vol. 50, No. 5, 1996, pp. 686-692.
Zawicki, et al, Amperometric Biosensors for Determination of Glucose, Maltose and Sucrose SPIE, vol. 2634, 0-8194--1999-095, pp. 179-183. 1995

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