Photometric instrument

Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation

Reexamination Certificate

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Reexamination Certificate

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08004673

ABSTRACT:
A metallic structure is provided on a surface of a substrate. A component having a longer wavelength than excitation light is detected from luminescence from fixation positions of biomolecules and emitted from a material other than the biomolecules, and is used for photometrical analysis. As the structure, usable is a particulate (a metallic structure of a size not larger than a wavelength of the excitation light), a minute protrusion, or a thin film with minute apertures, which are made of a metal such as gold, chrome, silver or aluminum. In the case of the particulate or the minute protrusion, photoluminescence of the structure is detected with a biomolecule being fixed thereon. In the case of the thin film with minute apertures, Raman scattered light of specimen solution around the biomolecules, and photoluminescence of the metallic structure near the biomolecules are detected with biomolecules being fixed in the apertures.

REFERENCES:
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patent: 7397559 (2008-07-01), Bratkovski
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patent: 9-257813 (1996-03-01), None
patent: 2005-70031 (2004-06-01), None
Takashi Funatsu et al., Imaging of Single Fluorescent Moleculres and individual ATP Turnovers by Single Myosin Molecules in Aqueous Solution:, Letters of Nature, vol. 374, Apr. 6, 1995, pp. 555-559.
European Search Report for corresponding European Patent Application No. 08020249.2-2217/2063258.

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