Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-12-05
2006-12-05
Paras, Jr., Peter (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C435S283100, C435S287800, C435S091500, C435S091500, C435S091500, C436S518000, C436S524000, C436S527000, C436S106000, C436S145000, C536S025300, C536S025310, C536S025320, C536S025330, C536S025340
Reexamination Certificate
active
07144700
ABSTRACT:
Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred groups of photolabile protecting moieties include: ((α-methyl-2-nitropiperonyl)-oxy)carbonyl (MeNPOC), ((Phenacyl)-oxy)carbonyl (PAOC), O-(9-phenylxanthen-9-yl) (PIXYL), and ((2-methylene-9,10-anthraquinone)-oxy)carbonyl (MAQOC). In conjunction with using the sensitizers and protecting groups described above, a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support is provided. These resulting solid-phase arrays are useful, for example, to assay for the presence of biochemical products in biological samples.
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Falvey Daniel E.
Feldman Brian M.
Fidanza Jacqueline A.
McGall Glenn
Affymetrix Inc.
Affymetrix, Inc.
Paras, Jr. Peter
Tran My-Chau T
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