Photolabile reagents for incorporation into oligonucleotide chai

Details Photolabile reagents for incorporation into oligonucleotide chai Photolabile reagents for incorporation into oligonucleotide chai

1989-08-25

1993-11-02

Yarbrough, Amelia B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 436501, 935 77, 935 78, 536 2532, C07H 2102

Patent

active

052585069

ABSTRACT:
Novel photolabile photochemical reagents are disclosed. The reagents are useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable sites into oligonucleotide or polynucleotide chains, i.e., sites which are cleavable upon photolysis. The reagents are also useful in both 5'- and 3'-phosphorylation of oligonucleotide or polynucleotide chains.

REFERENCES:
patent: 4302204 (1981-11-01), Wahl et al.
patent: 4775619 (1988-10-01), Urdea
patent: 5118605 (1992-06-01), Urdea
Gough et al, Tetrahedron Letters, 22 (1981) pp. 4177-4180.
J. Herbert et al., Can. J. Chem. 52:187-189 (1974).
M. Rubenstein et al., Tet. Lett. 17:1445-1448 (1975).

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