Photolabile compounds and methods for their use

Details Photolabile compounds and methods for their use Photolabile compounds and methods for their use

1995-06-23

1998-04-14

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562438, C07C20556

Patent

active

057393869

ABSTRACT:
Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.

REFERENCES:
patent: 4524186 (1985-06-01), Fodor
patent: 4593029 (1986-06-01), Venuti et al.
patent: 4670434 (1987-06-01), Venuti
patent: 4728502 (1988-03-01), Hamill
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5482719 (1996-01-01), Guillet
Abraham et al., 1991, Tetrahedron Letters, 32(5):577-580.
Barany et al., 1985, J. Am. Chem. Soc., 107:4936-4942.
Bellof et al., 1985, Chimia, 39(10):317-320.
Bush et al., 1988, Amer. J. Optometry Physiol. Optics, 65(9):722-728.
Cook et al., 1994, Tetrahedron Letters, 35(37):6777-6780.
Dugave et al., 1994, Tetrahedron Letters, 35(51):9557-9560 Synthesis of activated disulfide adducts containing a 4-diazocyclohexa-2,5-dienone precursor for photoaffinity labelling.
Fodor et al., 1991, Science, 251:767-777 Light-directed, spatially adressable parallel chemical synthesis.
Frank et al., 1988, Tetrahedron, 44:6031-6040 Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports.
Geysen et al., 1987, J. Immun. Meth., 102:259-274 Strategies for epitome analysis using peptide synthesis.
Green et al., 1975, Adv. Protein Chem., 29:85-133.
Greene et al., 1991, Protective Groups in Organic Synthesis, John Wiley: New York, pp, 1-362, see pages 27, 62, 88, 89, 315, 349 and 362.
Jones et al., 1987, Medicinal Chemistry, 30(2):295-303.
Merrifield, 1963, J. Am. Chem. Soc., 85:2149-2154 Solid phase peptide synthesis, 1. The synthesis of a peptide.
Nagakura et al., 1975, Heterocycles, 3(6):453-457.
Rajasekharan Pillai et al., 1980, J. Org. Chem., 45(26):5364-5370 New, easily removable poly(ethylene glycol) supports for liquid-phase method of peptide synthesis.
Rich et al., 1975, J. Am. Chem. Soc., 97:1575-1579 Preparation of a new o-nitrobenzyl resin for solid-phase synthesis of tert-butyloxycarbonyl-protected peptide acids.
Safar et al., Jun. 1994, 24th National Medicinal Chemistry Symposium, P206 Generation of Peptide-like libraries using amino acid-like subunits.
Surrey et al., 1958, J. Am. Chem. Soc., 80:3469-3471.
Teague, 1996, Tetrahedron Letters, 37(32):5751-5754 Facile synthesis of a o-nitrobenzyl photolabile linker for combinatorial chemistry.
Wang, 1976, J. Org. Chem., 41(20):3258-3261.
Yoo and Greenberg, 1995, J. Org. Chem., 60:3358-3364 Synthesis of oligonucleotides containing 3-alkyl carboxylic acids using universal, photolabile solid phase synthesis supports.

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