Photolabile caged ionophores and method of using in a membrane s

Details Photolabile caged ionophores and method of using in a membrane s Photolabile caged ionophores and method of using in a membrane s

1996-04-26

1999-03-30

Drodge, Joseph W.

Chemistry: analytical and immunological testing

Optical result

210649, 436514, 536 111, G01N 2100, G01N 33558, C07H 106

Patent

active

058888292

ABSTRACT:
The present invention describes a family of photolabile caged ionophores. The compounds of the present invention are photolytically cleavable esters of nigericin, ionomycin, A-23187, 4-Br-A-23187 and monensin. The photolysis of the present compounds allows the release of the free ionophore in vivo or in vitro with precise spatial and temporal control. The compounds are useful in the study of ion transport and control in cells and across membranes.

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