Photolabeling reagent

Details Photolabeling reagent Photolabeling reagent

1998-04-09

1999-11-16

Woodward, Michael P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

568332, 522 46, 524359, 562445, 564329, 514 2, C07C 49786

Patent

active

059861363

ABSTRACT:
Disclosed is a compound represent by the following structural formula: ##STR1## X is --H or an amine protecting group; --OY is --OH, an activating group for a carboxylic acid or a protecting group for a carboxylic acid; Z is --H or a phenolic protecting group, with the proviso that Z is not a straight chained, unsaturated alkyl group such as, for example, methyl or ethyl, and at least one of X, Y or Z is not --H.
Also disclosed is a photoreactive polypeptide having a polypeptide chain comprising a residue of the compound described above. Also disclosed is a method of labeling a target molecule which forms a complex with the photoreactive polypolypeptide by photolyzing the photoreactive polypeptide when complexed with the target molecule.

REFERENCES:
patent: 4442090 (1984-04-01), Kakeya
patent: 4757066 (1988-07-01), Shiokari
patent: 4762881 (1988-08-01), Kauer et al.
patent: 5266565 (1993-11-01), Lacoste
Tripp, J Med Chem 16, 60-64, 1973.
Wilson, Biochem 36, 4542, 1997.
Chem. Abstr. 47, 1639e, 1953.

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